Breast cancer therapy by laser-induced Coulomb explosion of gold nanoparticles
Breast cancer therapy by laser-induced Coulomb explosion of gold nanoparticles
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DOI：
10.3978/j.issn.1000-9604.2013.12.08
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发表时间：
2013-12-01
影响因子：
5.1
通讯作者：
Nadeem, Muhammad
中科院分区：
文献类型：
--
作者：
Ashiq, Muhammad Gul Bahar;Saeed, Mohammad Alain;Nadeem, Muhammad
目的：利用纳米光解技术研究激光诱导金纳米粒子库仑爆炸对乳腺癌的治疗作用。本研究的目的是探讨激光诱导库仑爆炸气泡的形成是否可以提供一种有效的方法来选择性地破坏乳腺癌的金纳米粒子。不同的参数相关的纳米光解，如激光能量密度，肿瘤深度，集群半径，激光脉冲持续时间，和气泡的形成进行了数值研究。结果：直径为10、20、30、40和50 nm的金纳米粒子分别能穿透肿瘤1.14、1.155、1.189、1.20和1.22 cm。在肿瘤中的最大穿透深度可以用50nm半径的纳米颗粒获得。40ns的短脉冲激光与半径为10nm的纳米粒子可以穿透肿瘤深度为1.14cm。半径为9 pm的气泡可以有效杀死乳腺癌细胞，而不会损害健康细胞。气泡半径从4增加到9 pm，在10至30 ns的范围内的脉冲持续时间的增加。结论：金纳米粒子的半径和气泡形成的乳腺癌细胞的选择性损伤成功地探测。本文的计算结果与其他实验结果进行了比较，发现本文的工作和以前的实验值之间有很好的相关性。已经证明，肿瘤中的气泡形成可以进一步增加乳腺癌治疗的功效。
Objective: Laser-induced Coulomb explosion of gold nanoparticles for breast cancer has been studied by nanophotolysis technique. This study aimed to investigate whether laser-induced bubble formation due to Coulomb explosion can provide an effective approach for selective damage of breast cancer with gold nanoparticles.Method: Numerical method involves laser-induced Coulomb explosion of gold nanoparticles. Different parameters related to nanophotolysis such as laser fluence, tumor depth, cluster radius, laser pulse duration, and bubble formation is studied numerically. Numerical simulation was performed using Mat lab.Results: The gold nanoparticles of 10, 20, 30, 40, and 50 nm in radius could penetrate into tumor 1.14, 1.155, 1.189, 1.20 and 1.22 cm in depth respectively. The maximum penetration depth in tumor could be obtained with nanoparticles of 50 nm radius. Short laser pulse of 40 ns with nanoparticles of 10 nm radius could penetrate into tumor 1.14 cm in depth. Bubbles with a radius of 9 pm could effectively kill breast cancer cells without damaging healthy ones. The bubble radius increased from 4 to 9 pm with an increase in pulse duration in the range of 10 to 30 ns.Conclusions: Gold nanopartides with increasing radius and bubble formation for selective damage of breast cancer cells are successfully probed. The present calculated results are compared with other experimental findings, and good correlation is found between the present work and previous experimental values. It was demonstrated that bubble formation in tumor may further increase the efficacy of breast cancer treatment.