Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid-Structure Interaction Approach.
Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid-Structure Interaction Approach.
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患者特异性二叶主动脉瓣生物力学：磁共振成像集成流体-结构相互作用方法。
DOI：
10.1007/s10439-020-02571-4
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发表时间：
2021-03
影响因子：
3.8
通讯作者：
Bluestein D
中科院分区：
文献类型：
--
作者：
Emendi M;Sturla F;Ghosh RP;Bianchi M;Piatti F;Pluchinotta FR;Giese D;Lombardi M;Redaelli A;Bluestein D
先天性二叶式主动脉瓣（BAV）由两个融合的瓣尖组成，是钙化性瓣膜狭窄的主要危险因素。在此，完全耦合的流体-结构相互作用（FSI）BAV模型是从患者特异性磁共振成像（MRI）中开发的，并与体内四维流动MRI（4D Flow）进行比较。FSI模拟与4D Flow进行了良好比较，确认了冲击主动脉壁的射流方向和大小以及收缩期形成的二次流和涡流的位置和范围：源自椭圆形1.6 cm 2瓣口的收缩期射流达到峰值速度252.2 cm/s，比4D Flow低0.6%，逐渐冲击升主动脉凸面。FSI模型预测的峰值流速为22.4 l/min，比4D Flow高6.7%，并提供了无法通过MRI直接获得的BAV瓣叶机械和流动诱导剪切应力。在收缩期，未融合瓣叶的心室侧显示出最高的壁面剪切应力（WSS）平均值，沿游离缘高达14.6 Pa沿着，WSS向腹部逐渐降低。在舒张期，融合瓣叶的主动脉侧表现出最高的舒张期最大主应力，在附着区域内高达322 kPa。与真实无创MRI的系统比较可以提高计算模型更真实地再现自体BAV血流动力学和生物力学反应的能力，并阐明其在BAV患者发生并发症风险中的作用;该方法可能进一步有助于验证旨在评估BAV生物力学的高级FSI模拟。
Congenital bicuspid aortic valve (BAV) consists of two fused cusps and represents a major risk factor for calcific valvular stenosis. Herein, a fully coupled fluid-structure interaction (FSI) BAV model was developed from patient-specific magnetic resonance imaging (MRI) and compared against in vivo 4-dimensional flow MRI (4D Flow). FSI simulation compared well with 4D Flow, confirming direction and magnitude of the flow jet impinging onto the aortic wall as well as location and extension of secondary flows and vortices developing at systole: the systolic flow jet originating from an elliptical 1.6 cm2 orifice reached a peak velocity of 252.2 cm/s, 0.6% lower than 4D Flow, progressively impinging on the ascending aorta convexity. The FSI model predicted a peak flow rate of 22.4 l/min, 6.7% higher than 4D Flow, and provided BAV leaflets mechanical and flow-induced shear stresses, not directly attainable from MRI. At systole, the ventricular side of the non-fused leaflet revealed the highest wall shear stress (WSS) average magnitude, up to 14.6 Pa along the free margin, with WSS progressively decreasing towards the belly. During diastole, the aortic side of the fused leaflet exhibited the highest diastolic maximum principal stress, up to 322 kPa within the attachment region. Systematic comparison with ground-truth non-invasive MRI can improve the computational model ability to reproduce native BAV hemodynamics and biomechanical response more realistically, and shed light on their role in BAV patients’ risk for developing complications; this approach may further contribute to the validation of advanced FSI simulations designed to assess BAV biomechanics.
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影响因子：
3.8
作者：
Aggarwal, Ankush;Ferrari, Giovanni;Joyce, Erin;Daniels, Michael J.;Sainger, Rachana;Gorman, Joseph H., III;Gorman, Robert;Sacks, Michael S.
通讯作者：
Sacks, Michael S.
影响因子：
3.5
作者：
Aggarwal, Ankush;Sacks, Michael S.
通讯作者：
Sacks, Michael S.
DOI：
10.1016/j.jtcvs.2010.01.016
发表时间：
2010-10-01
影响因子：
6
作者：
Conti, Carlo A.;Della Corte, Alessandro;Redaelli, Alberto
通讯作者：
Redaelli, Alberto
影响因子：
24
作者：
Kong, William K. F.;Delgado, Victoria;Bax, Jeroen J.
通讯作者：
Bax, Jeroen J.
DOI：
10.1186/1532-429x-15-51
发表时间：
2013-06-13
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Fratz S;Chung T;Greil GF;Samyn MM;Taylor AM;Valsangiacomo Buechel ER;Yoo SJ;Powell AJ
通讯作者：
Powell AJ