Data on the association of the nuclear envelope protein Sun1 with nucleoli.
Data on the association of the nuclear envelope protein Sun1 with nucleoli.
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DOI：
10.1016/j.dib.2017.05.028
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发表时间：
2017-08
期刊：
影响因子：
1.2
通讯作者：
Stochaj U
中科院分区：
文献类型：
--
作者：
Moujaber O;Omran N;Kodiha M;Pié B;Cooper E;Presley JF;Stochaj U
SUN蛋白参与多种细胞活动，其中许多与核膜有关。最近，家族成员SUN1与新的生物活性有关。这些包括调节核仁，组装核糖体亚单位的核内隔室。我们发现，SUN1协会与核仁在几种哺乳动物上皮细胞系。并非所有细胞类型都具有这种核仁定位，因为SUN1集中在神经节神经元和非神经元卫星细胞的核膜上。数据库分析和蛋白质印迹法强调了SUN1蛋白在不同哺乳动物细胞中的复杂性。我们构建了一个STRING网络，该网络将SUN1相关蛋白识别为包括几种核仁蛋白的更大网络的一部分。总之，目前的数据突出了SUN1蛋白的多样性，并强调了SUN1和核仁之间可能的联系。
SUN proteins participate in diverse cellular activities, many of which are connected to the nuclear envelope. Recently, the family member SUN1 has been linked to novel biological activities. These include the regulation of nucleoli, intranuclear compartments that assemble ribosomal subunits. We show that SUN1 associates with nucleoli in several mammalian epithelial cell lines. This nucleolar localization is not shared by all cell types, as SUN1 concentrates at the nuclear envelope in ganglionic neurons and non-neuronal satellite cells. Database analyses and Western blotting emphasize the complexity of SUN1 protein profiles in different mammalian cells. We constructed a STRING network which identifies SUN1-related proteins as part of a larger network that includes several nucleolar proteins. Taken together, the current data highlight the diversity of SUN1 proteins and emphasize the possible links between SUN1 and nucleoli.