Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish.
Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish.
复制标题
DOI：
10.1002/bdrc.20007
复制
发表时间：
2004-06-01
期刊：
影响因子：
--
通讯作者：
Schilling, Thomas F
中科院分区：
文献类型：
--
作者：
Clouthier, David E;Schilling, Thomas F
面部和颈部的形态发生是由组织成分级通路的信号分子和转录因子的复杂中继驱动的。这些通路的协调作用调节咽弓内神经嵴细胞的发育，导致骨、软骨和结缔组织的适当时空形成。虽然参与这些过程的许多基因的功能最初是通过在小鼠中使用敲除技术阐明的，但越来越多的斑马鱼颅面突变体导致了颅面发育相关基因的鉴定迅速扩大。对小鼠和斑马鱼之间参与这些过程的信号通路进行比较分析，不仅有可能查明颅面发育中保守的关键基因功能，而且还可以快速识别和研究下游效应子。这些互补的方法也将允许快速识别候选基因和基因功能在人类颅面畸形中被破坏。在这篇简短的综述中，我们对颅面发育中涉及的一种分子内皮素-1进行了比较分析，内皮素-1是一种小的分泌蛋白，对形成下颌和喉咙结构的神经嵴细胞的图案至关重要。
Morphogenesis of the face and neck is driven by an intricate relay of signaling molecules and transcription factors organized into hierarchical pathways. The coordinated action of these pathways regulates the development of neural crest cells within the pharyngeal arches, resulting in proper spatiotemporal formation of bone, cartilage, and connective tissue. While the functions of many genes involved in these processes were initially elucidated through the use of knockout technology in the mouse, increasing numbers of zebrafish craniofacial mutants have led to a rapid expansion in the identification of genes involved in craniofacial development. A comparative analysis of signaling pathways involved in these processes between mouse and zebrafish holds the potential not only to pinpoint conserved and therefore crucial gene functions in craniofacial development, but also to rapidly identify and study downstream effectors. These complementary approaches will also allow rapid identification of candidate genes and gene functions disrupted in human craniofacial dysmorphologies. In this brief review, we present a comparative analysis of one molecule involved in craniofacial development, endothelin-1, a small, secreted protein that is crucial for patterning the neural crest cells that give rise to lower jaw and throat structures.