MAST-CELLS IN BRAINS DURING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN LEWIS RATS
MAST-CELLS IN BRAINS DURING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN LEWIS RATS
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DOI：
10.1016/0022-510x(91)90136-u
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发表时间：
1991-10-01
影响因子：
4.4
通讯作者：
MORK, S
中科院分区：
文献类型：
--
作者：
BO, L;OLSSON, T;MORK, S
用豚鼠脊髓和弗氏完全佐剂诱发急性实验性变态反应性脑脊髓炎（EAE），观察刘易斯大鼠脑内肥大细胞数量及其脱颗粒程度。在免疫后（p.i.）第10、11、12和16天处死未免疫对照和EAE大鼠。EAE脑内脱颗粒肥大细胞比例明显增加。早在感染后第10天就观察到脱粒迹象。从感染后第10天开始出现临床EAE体征。未观察到肥大细胞数量的显著变化。去颗粒细胞的百分比在感染后第16天最大，此时炎症已到达丘脑。这表明肥大细胞脱颗粒可能是炎症的结果。总的来说，这些数据表明，肥大细胞可能在EAE的发病机制中发挥作用。
We studied the number of mast cells and their extent of degranulation in brains of Lewis rats with acute experimental allergic encephalomyelitis (EAE), actively induced with guinea pig spinal cord and Freund's complete adjuvant. Non-immunized controls and EAE rats were killed on days 10, 11, 12, and 16 post-immunization (p.i.). The percentage of degranulated mast cells was significantly increased in EAE brains. Signs of degranulation were observed as early as day 10 p.i. Clinical EAE signs appeared from day 10 p.i. A significant change in mast cell number was not observed. The percentage of degranulated cells was largest at day 16 p.i., at a time when the inflammation had reached the thalamus. This indicates that mast cell degranulation may occur as a result of the inflammation. Collectively, the data suggest that mast cells may play a role in the pathogenesis of EAE.