Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia
Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia
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DOI：
10.1155/2013/303859
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Lip, Gregory Y. H.
中科院分区：
文献类型：
--
作者：
Chackathayil, Julia;Patel, Jeetesh V.;Lip, Gregory Y. H.
患有缺铁性贫血(IDA)的男性患糖尿病的风险显著降低。鉴于南亚人和非洲加勒比人对糖尿病的易感性增加，这种关系在妇女中的性质尚不清楚，也没有关于种族影响的信息。我们回顾了2000-2007年间确诊为贫血的3563例患者。计算了年龄调整后的维生素B12缺乏和IDA患病率，以及高加索人、南亚人和非洲加勒比人的心血管并发症。南亚人缺乏维生素B12(仅限妇女)或缺铁性贫血的患病率明显高于高加索人和非洲加勒比人。在患有缺铁性贫血的妇女中，南亚人的糖尿病患病率(45%，95%可信区间39.0-51.0)高于高加索人(3.0%，2.1-4.0)；P<；0.001。在缺乏维生素B12的南亚妇女中，糖尿病患病率降低了8.5%(5.2-12.0)。缺乏维生素B12的南亚女性心肌梗死(MI)和缺血性心脏病(IHD)的患病率更高，但这种关系在IDA中正好相反。在南亚女性中，IDA与糖尿病的患病率更高有关，但与大血管并发症的更大风险并不一致。考虑到南亚人糖尿病对心血管的影响，这种联系值得进一步研究其病理生理学意义。
The risk of diabetes is markedly reduced in men with iron deficiency anaemia (IDA). The nature of this relationship in women is not clear, nor is there information about the influence of ethnicity, given the increased susceptibility of diabetes amongst South Asians and Afro-Caribbeans. We reviewed 3563 patients with a diagnosis of anaemia from 2000 to 2007. The age-adjusted prevalence of vitamin B12 deficiency and IDA was calculated, together with cardiovascular comorbidities amongst Caucasians, South Asians, and Afro-Caribbeans. The prevalence of vitamin B12 deficiency (women only) or IDA was markedly higher in South Asians compared to Caucasians and Afro-Caribbeans. Among women with IDA, diabetes was more prevalent among South Asians (45%, 95% CI 39.0-51.0) compared to Caucasians (3.0%, 2.1-4.0); p < 0.001. Among South Asian women with vitamin B12 deficiency, the prevalence of diabetes was reduced 8.5% (5.2-12.0). South Asian women with vitamin B12 deficiency had a higher prevalence of myocardial infarction (MI) and ischemic heart disease (IHD), but this relationship was reversed in IDA. IDA is associated with a greater prevalence of diabetes in South Asian women, but it is not coordinated by a greater risk of macrovascular complications. Given the cardiovascular impact of diabetes in South Asians, this association merits further study in relation to its pathophysiological implication.