Oxidative stress and atherosclerosis.
Oxidative stress and atherosclerosis.
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DOI：
10.1007/s11883-005-0013-5
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发表时间：
2005-05-01
影响因子：
5.8
通讯作者：
Lee, Richard T
中科院分区：
文献类型：
--
作者：
Schulze, P Christian;Lee, Richard T
了解动脉粥样硬化的病理生理学可以为预防和治疗这种常见疾病的患者提供新的策略。临床、流行病学和基础分子科学研究已经确定氧化应激是动脉粥样硬化发生和发展的一个因素。氧化应激也参与内皮功能障碍和高血压的发病机制，这是许多动脉粥样硬化患者的两个重要因素。此外，它有助于疾病进展的机制，如脂质氧化和血管重塑。本文就活性氧和氧化应激在动脉粥样硬化中的作用作一综述。
Understanding of the pathophysiology of atherosclerosis can provide new strategies for the prevention and treatment of patients with this common disease. Clinical, epidemiologic, and basic molecular science studies have identified oxidative stress as a factor contributing to the development and progression of atherosclerosis. Oxidative stress also participates in the pathogenesis of endothelial dysfunction and hypertension, two important factors in many patients with atherosclerosis. Further, it contributes to mechanisms of disease progression such as lipid oxidation and vascular remodeling. This article reviews the role of reactive oxygen species and oxidative stress in atherosclerosis.