Engineered Microenvironments for Human Stem Cells
Engineered Microenvironments for Human Stem Cells
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DOI：
10.1002/bdrc.20138
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发表时间：
2008-12-01
影响因子：
2.1
通讯作者：
Vunjak-Novakovic, Gordana
中科院分区：
文献类型：
--
作者：
Godier, Amandine F. G.;Marolt, Darja;Vunjak-Novakovic, Gordana
细胞分化和组装的调控仍然是发育生物学中的一个基本问题。在发育过程中，组织从干细胞的更新、分化和组装的协调序列中出现。同样，成体组织的再生是由修复细胞的迁移和分化驱动的。干细胞和再生医学领域开始意识到细胞环境的整个背景是多么重要，其他细胞，三维基质以及分子和物理形态发生序列的存在。前提是，为了释放干细胞的全部潜力，至少需要在体外使用的实验系统中重建通常存在于体内的动态环境的某些方面。我们在这里回顾了一些最近的工作，利用工程环境指导胚胎和成人干细胞，并专注于血管生成作为一个关键的和普遍重要的方面，组织发育和再生。出生缺陷研究（C部分）84：335-347，2008年。(C)2008 Wiley-Liss，Inc.
Regulation of cell differentiation and assembly remains a fundamental question in developmental biology. During development, tissues emerge from coordinated sequences of the renewal, differentiation, and assembly of stem cells. Likewise, regeneration of an adult tissue is driven by the migration and differentiation of repair cells. The fields of stem cells and regenerative medicine are starting to realize how important is the entire context of the cell environment, with the presence of other cells, three-dimensional matrices, and sequences of molecular and physical morphogens. The premise is that to unlock the full potential of stem cells, at least some aspects of the dynamic environments normally present in vivo need to be reconstructed in experimental systems used in vitro. We review here some recent work that utilized engineered environments for guiding the embryonic and adult human stem cells, and focus on vasculogenesis as a critical and universally important aspect of tissue development and regeneration. Birth Defects Research (Part C) 84:335-347, 2008. (C) 2008 Wiley-Liss, Inc.