Elevated levels of perfluoroalkyl acids in family members of occupationally exposed workers: the importance of dust transfer.
Elevated levels of perfluoroalkyl acids in family members of occupationally exposed workers: the importance of dust transfer.
复制标题
职业暴露工人家庭成员的全氟烷基酸水平升高：粉尘转移的重要性
DOI：
10.1038/srep09313
复制
发表时间：
2015-03-20
影响因子：
4.6
通讯作者：
Jiang G
中科院分区：
文献类型：
--
作者：
Fu J;Gao Y;Wang T;Liang Y;Zhang A;Wang Y;Jiang G
由于复杂的生活环境，全氟烷基酸（PFAAs）在人体中的暴露途径尚不清楚，很少有研究同时研究不同PFAAs在人体中的生物累积行为。在这项研究中，血清，灰尘，重复的饮食和其他基质收集周围的一个制造厂在中国和同源系列的PFAA进行了分析。该地区居民血清和粉尘中PFAA水平明显高于非污染区。虽然饮食摄入是本研究中的主要暴露途径，但粉尘摄入在这种情况下发挥了重要作用。当地居民血清PFAAs水平与生活或工作微环境粉尘PFAAs水平显著相关。职业工人家属（FM）血清PFAAs和粉尘PFAAs均显著高于普通居民（OR）（P < 0.01）。在仔细分析了PFAAs的暴露途径后，除了直接摄入灰尘外，还提出了一个潜在的途径：PFAAs可能通过烹饪过程从职业工人的衣服转移到晚餐。PFHxS和PFOS的生物累积潜力高于其他PFAAs，说明全氟磺酸和全氟羧酸的生物累积能力存在较大差异。
The exposure pathways of perfluoroalkyl acids (PFAAs) to humans are still not clear because of the complex living environment and few studies have simultaneously investigated the bioaccumulative behaviour of different PFAAs in humans. In this study, serum, dust, duplicate diet and other matrices were collected around a manufacturing plant in China and homologous series of PFAAs were analysed. PFAA levels in dust and serum of local residents in this area were considerably higher than those in non-polluted area. Although dietary intake was the major exposure pathway in the present study, dust ingestion played an important role in this case. Serum PFAAs in local residents was significantly correlated with dust PFAAs levels in their living or working microenvironment. Serum PFAAs and dust PFAAs were significantly higher in family members of occupational workers (FM) than in ordinary residents (OR) (p < 0.01). After a careful analysis of the PFAAs exposure pathway, a potential pathway in addition to direct dust ingestion was suggested: PFAAs might transferred from occupational worker's clothes to dinners via cooking processes. The bioaccumulative potential of PFHxS and PFOS were higher than other PFAAs, which suggested a substantial difference between the bioaccumulative ability of perfluorinated sulfonic acids and perfluorinated carboxylic acids.