The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: a transporter for steroid-derived molecules.
The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: a transporter for steroid-derived molecules.
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DOI：
10.1016/j.mam.2012.11.005
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发表时间：
2013-04
影响因子：
10.6
通讯作者：
Hammond, Christine L.
中科院分区：
文献类型：
--
作者：
Ballatori, Nazzareno;Christian, Whitney V.;Wheeler, Sadie G.;Hammond, Christine L.
有机溶质转运体α-β（OSTα-OSTβ）是溶质载体家族的最新成员之一，命名为SLC 51，可以说是最独特的成员之一。该转运蛋白由SLC 51 A和SLC 51 B编码的两种基因产物组成，这两种基因产物异源二聚化以形成功能性转运蛋白复合物。SLC 51 A编码OSTα，一种预测的340个氨基酸的7-跨膜（TM）结构域蛋白，而SLC 51 B编码OSTβ，一种推定的128个氨基酸的单-TM结构域多肽。两个亚基的异源二聚化增加了单个蛋白质的稳定性，促进了它们的翻译后修饰，并且是将功能性转运蛋白复合物递送至质膜所需的。在已检查的任何基因组中没有SLC 51 A或SLC 51 B的旁系同源物。转运蛋白通过易化扩散机制发挥作用，并可根据其底物的电化学梯度介导流出或摄取。总体而言，转运蛋白的底物特异性、转运机制、组织分布、亚细胞定位和转录调控以及最近产生的Slc 51 a缺陷小鼠的表型的表征揭示了OSTα-OSTβ在胆汁酸、结合类固醇和结构相关分子穿过许多上皮细胞的基底外侧膜的转运中起着核心作用。特别是，OSTα-OSTβ似乎对肠道胆汁酸吸收至关重要，因此对膳食脂质吸收至关重要。
The organic solute transporter alpha-beta (OSTα-OSTβ) is one of the newest members of the solute carrier family, designated as SLC51, and arguably one of the most unique. The transporter is composed of two gene products encoded by SLC51A and SLC51B that heterodimerize to form the functional transporter complex. SLC51A encodes OSTα, a predicted 340-amino acid, 7-transmembrane (TM) domain protein, whereas SLC51B encodes OSTβ, a putative 128-amino acid, single-TM domain polypeptide. Heterodimerization of the two subunits increases the stability of the individual proteins, facilitates their post-translational modification, and is required for delivery of the functional transporter complex to the plasma membrane. There are no paralogues for SLC51A or SLC51B in any genome that has been examined. The transporter functions via a facilitated diffusion mechanism, and can mediate either efflux or uptake depending on the electrochemical gradient of its substrates. Overall, characterization of the transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, and transcriptional regulation as well as the phenotype of the recently generated Slc51a-deficient mice have revealed that OSTα-OSTβ plays a central role in the transport of bile acids, conjugated steroids, and structurally-related molecules across the basolateral membrane of many epithelial cells. In particular, OSTα-OSTβ appears to be essential for intestinal bile acid absorption, and thus for dietary lipid absorption.
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影响因子：
7.7
作者：
Huang, Xinqiang;Yang, Chaofeng;McKeehan, Wallace L.
通讯作者：
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DOI：
10.1152/ajpgi.00539.2005
发表时间：
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作者：
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DOI：
10.1152/ajpgi.00479.2005
发表时间：
2006-05-01
影响因子：
4.5
作者：
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通讯作者：
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