INVOLVEMENT OF THE AMYGDALA IN THE EFFECT OF ANTI-DEPRESSANTS ON THE PASSIVE-AVOIDANCE DEFICIT IN BULBECTOMIZED RATS
INVOLVEMENT OF THE AMYGDALA IN THE EFFECT OF ANTI-DEPRESSANTS ON THE PASSIVE-AVOIDANCE DEFICIT IN BULBECTOMIZED RATS
复制标题
DOI：
10.1007/bf00431759
复制
发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
LLOYD, KG
中科院分区：
文献类型：
--
作者：
GARRIGOU, D;BROEKKAMP, CL;LLOYD, KG
抗抑郁药和药物对球茎切除大鼠被动回避学习的影响证明了杏仁核的作用。将丙咪嗪、阿米替林或氟西汀双侧注射(2×10μg)至杏仁核内侧部分可改善球切除大鼠的被动回避学习。用美角林进行全身预处理会减弱局部丙咪嗪或氟西汀注射的效果。将血清素而不是去甲肾上腺素（去甲肾上腺素）显微注射到杏仁核中可以改善球切除大鼠的被动回避学习。讨论了杏仁核在动物抗抑郁药行为影响中的相关性。
The role of the amygdala is demonstrated in the effect of antidepressant and drugs on passive avoidance learning in bulbectomized rats. Imipramine, amitriptyline or fluoxetine injected bilaterally (2 .times. 10 .mu.g) into the medial part of the amygdala improves passive avoidance learning by bulbectomized rats. Systemic pretreatment with methergoline attenuates the effect of local imipramine or fluoxetine injection. Microinjection of serotonin but not noradrenaline (norepinephrine) into the amygdala improves passive avoidance learning by bulbectomized rats. The relevance of the amygdala in the behavioral effects of antidepressants in animals is discussed.