Broken asymmetry of the human heartbeat: Loss of time irreversibility in aging and disease
Broken asymmetry of the human heartbeat: Loss of time irreversibility in aging and disease
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DOI：
10.1103/physrevlett.95.198102
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发表时间：
2005-11-04
影响因子：
8.6
通讯作者：
Peng, CK
中科院分区：
文献类型：
--
作者：
Costa, M;Goldberger, AL;Peng, CK
时间不可逆性是非平衡系统的一个基本属性，在评估在大范围尺度上运行的生理过程的状态时，时间不可逆性应该是重要的。然而，在生命系统中对这种特性的测量一直是有限的。我们提供了一种基于基本物理假设的计算方法来量化多个尺度上的时间不对称性，并将其应用于健康和疾病中的心跳时间序列。我们发现，年轻受试者的时间序列的多尺度时间不对称指数最高，并随着年龄的增长或心脏病的发生而降低。失去时间的不可逆性可能会提供一种新的方法来评估远离平衡运行的生命系统的功能。
Time irreversibility, a fundamental property of nonequilibrium systems, should be of importance in assessing the status of physiological processes that operate over a wide range of scales. However, measurement of this property in living systems has been limited. We provide a computational method derived from basic physics assumptions to quantify time asymmetry over multiple scales and apply it to the human heartbeat time series in health and disease. We find that the multiscale time asymmetry index is highest for a time series from young subjects and decreases with aging or heart disease. Loss of time irreversibility may provide a new way of assessing the functionality of living systems that operate far from equilibrium.