The role of FAS to ezrin association in FAS-mediated apoptosis
The role of FAS to ezrin association in FAS-mediated apoptosis
复制标题
DOI：
10.1007/s10495-005-0478-2
复制
发表时间：
2005-10-01
期刊：
影响因子：
7.2
通讯作者：
Lozupone, F
中科院分区：
文献类型：
--
作者：
Fais, S;De Milito, A;Lozupone, F
获得细胞极性是许多细胞功能（包括细胞凋亡）的关键要求。细胞极化是肌动蛋白细胞骨架驱动的过程，通过肌动蛋白和越来越多的膜蛋白之间的连接来实现。与此相关的主要参与者是埃兹蛋白（ezrin）、根蛋白（radixin）和莫斯蛋白（moesin），它们是具有高度同源性的蛋白质家族。它们的结构包括一个与膜蛋白连接的表位和另一个与肌动蛋白分子结合的表位。在这篇综述中，我们讨论了最近的数据，这些数据表明 Fas 与肌动蛋白细胞骨架的连接是由埃兹蛋白介导的，并且它是对 Fas 介导的细胞凋亡敏感的基本要求。负责 Fas 结合的埃兹蛋白区域由 18 个氨基酸组成，位于埃兹蛋白 FERM 结构域的中叶。这种结合是特异性的，并且在细胞稳态的控制中至关重要。此外，Fas-ezrin 共定位、ezrin 磷酸化和早期获得对 Fas 介导的细胞凋亡的敏感性可能在某些人类疾病中发挥作用，其中程序性细胞死亡似乎是其主要发病机制，例如艾滋病。
The acquisition of a cell polarity is a crucial requirement for a number of cellular functions, including apoptosis. Cell polarization is an actin cytoskeleton-driven process, through a connection between actin and an increasing number of membrane proteins. The major actors in this connection are ezrin, radixin and moesin, a family of proteins with a high level of homology. Their structure includes an epitope that links to membrane proteins and the other that binds to the actin molecule. In this review we discuss recent data showing that the Fas linkage to the actin cytoskeleton is ezrin mediated and it is an essential requirement for susceptibility to the Fas-mediated apoptosis. The ezrin region responsible of Fas binding consists of 18 aminoacids mapped on the median lobe of the ezrin FERM domain. This binding is specific and of key importance in the control of cell homeostasis. Moreover, Fas-ezrin co-localization, ezrin phosphorylation and early acquisition of susceptibility to Fas-mediated apoptosis, may have a role in some human diseases in which programmed cell death seems to be a central pathogenetic mechanism, such as AIDS.