Intramolecular palladium-catalyzed allylic alkylation: Enantio- and diastereoselective synthesis of [2.2.2] bicycles
Intramolecular palladium-catalyzed allylic alkylation: Enantio- and diastereoselective synthesis of [2.2.2] bicycles
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DOI：
10.1021/ol0265766
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发表时间：
2002-10-03
期刊：
影响因子：
5.2
通讯作者：
Asakawa, N
中科院分区：
文献类型：
--
作者：
Trost, BM;Sacchi, KL;Asakawa, N
Pd催化的不对称烯丙基烷基化在形成双环[2.2.2]辛-2，3-二酮和奎宁环-2-酮（后者是奎宁生物碱的潜在前体）时提供了对映体和非对映体选择性。
[GRAPHICS]Pd-catalyzed asymmetric allylic alkylation provides both enantio- and diastereoselectivity in formation of bicyclo [2.2.2] octan-2,3-diones and quinuclidin-2-ones, the latter potential precursors to quinine alkaloids.