Enhanced anti-HCV activity of interferon alpha 17 subtype.
Enhanced anti-HCV activity of interferon alpha 17 subtype.
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DOI：
10.1186/1743-422x-6-70
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发表时间：
2009-06-03
期刊：
影响因子：
4.8
通讯作者：
Duverlie G
中科院分区：
文献类型：
--
作者：
Dubois A;François C;Descamps V;Fournier C;Wychowski C;Dubuisson J;Castelain S;Duverlie G
聚乙二醇化干扰素α2(a或b)联合利巴韦林是治疗慢性丙型肝炎最有效的方法，但很大一部分患者对治疗没有反应。因此，提高治疗效果是很有意义的。干扰素α是一种由12种不同亚型组成的I型干扰素。每个亚型都通过Jak-Stat途径发出信号，但在抗病毒活性中的调节作用已在前面描述过。利用丙型肝炎病毒(HCV)培养系统，我们检测了每个干扰素α亚型的抗丙型肝炎病毒活性。我们分析了各亚型对丙型肝炎病毒增殖和某些亚型的细胞信号通路的影响。不同亚型的干扰素对丙型肝炎病毒的作用不同。我们发现，干扰素α17对丙型肝炎病毒的治疗效率是干扰素α2a的三倍。这种效率与对Jak-Stat通路的更强刺激有关。我们建议对干扰素α17进行治疗性检测，以期提高治疗效果。
Pegylated interferon alpha 2 (a or b) plus ribavirin is the most effective treatment of chronic hepatitis C but a large proportion of patients do not respond to therapy. So, it is interesting to improve the treatment efficacy. Interferon alpha is a type I interferon composed of 12 different subtypes. Each subtype signals by the Jak-Stat pathway but modulations in the antiviral activity was previously described. Using the hepatitis C virus (HCV) culture system, we have tested the anti-HCV activity of each interferon alpha subtypes. We have analyzed the effect of each subtype on the HCV multiplication and the cell-signaling pathway for some subtypes. There were divergent effects of IFN alpha subtypes against HCV. We have found that IFN alpha 17 was three times more efficient than IFN alpha 2a on HCV. This efficiency was related to a stronger stimulation of the Jak-Stat pathway. We suggest that IFN α17 should be tested therapeutically with a view to improving treatment efficacy.