HIGHLY STEREOSELECTIVE ASYMMETRIC HYDROGENATION OF 2-BENZAMIDOMETHYL-3-OXOBUTANOATE CATALYZED BY CATIONIC BINAP RUTHENIUM(II) COMPLEXES
HIGHLY STEREOSELECTIVE ASYMMETRIC HYDROGENATION OF 2-BENZAMIDOMETHYL-3-OXOBUTANOATE CATALYZED BY CATIONIC BINAP RUTHENIUM(II) COMPLEXES
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DOI：
10.1039/c39910000609
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发表时间：
1991-05-01
影响因子：
--
通讯作者：
TAKAYA, H
中科院分区：
文献类型：
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作者：
MASHIMA, K;MATSUMURA, Y;TAKAYA, H
以[Rul{（R）-binap}（p-cymene）] 1及其衍生物的配合物为催化剂，实现了2-苯甲酰氨基甲基-3-氧代丁酸甲酯的高非对映选择性氢化，得到了（2S，3R）-2-苯甲酰氨基甲基-3-羟基丁酸甲酯，其非对映异构体过量高达98%，对映异构体过量高达99%。
Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate has been accomplished by using [Rul{(R)-binap}(p-cymene)]l and corresponding complexes of derivatives of binap as catalyst, giving methyl (2S,3R)-2-benzamidomethyl-3-hydroxybutanoate, a versatile intermediate for the synthesis of beta-lactam antibiotics, in up to 98% diastereoisomeric excess and 99% enantiomeric excess.