The neurocognitive performance of drug-free and medicated euthymic bipolar patients do not differ
The neurocognitive performance of drug-free and medicated euthymic bipolar patients do not differ
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DOI：
10.1111/j.1600-0447.2009.01390.x
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发表时间：
2009-12-01
影响因子：
6.7
通讯作者：
Moore, P. B.
中科院分区：
文献类型：
--
作者：
Goswami, U.;Sharma, A.;Moore, P. B.
目的：虽然已确定心境双相患者存在神经认知障碍，但药物对其认知表现的影响尚不确定，需要进一步研究。方法：对44例经前瞻性验证的I型心境双相情感障碍患者进行执行功能、记忆和注意神经心理测试，其中22例为非药物患者。剩余情绪症状效应采用方差分析进行统计学控制。结果：无药物和服药患者仅在延迟言语回忆（Rey AVLT列表A7，无药物>用药）和五点测试期间的持久性（无药物>用药）方面存在差异。当残余情绪症状得到统计控制时，未用药和服药受试者之间的差异变得微不足道。药物效应大小适中。残差抑郁得分与言语学习测量结果之间存在显著相关性。结论：药物对神经认知表现没有显著影响，提示神经认知缺陷是双相情感障碍的一个组成部分。
Objective:Although it is established that euthymic bipolar patients have neurocognitive deficits, the influence of medication on their cognitive performance is uncertain and requires investigation.Method:Neuropsychological tests of executive function, memory and attention were performed on 44 prospectively verified, euthymic bipolar I patients, 22 of whom were drug-free. Residual mood symptom effects were controlled statistically using ancova.Results:Drug-free and medicated patients differed only in delayed verbal recall (Rey AVLT list A7, drug-free > medicated), and perseverations during the five-point test (drug-free > medicated). When residual mood symptoms were controlled statistically, differences between drug-free and medicated subjects became insignificant. Medication effect sizes were modest. Significant correlations were found between residual depression scores and measures of verbal learning.Conclusion:Medications did not have any significant influence on neurocognitive performance, suggesting that neurocognitive deficits are an integral part of bipolar disorder.