Excess of high frequency electroencephalogram oscillations in boys with autism
Excess of high frequency electroencephalogram oscillations in boys with autism
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DOI：
10.1016/j.biopsych.2006.12.029
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发表时间：
2007-11-01
影响因子：
10.6
通讯作者：
Elam, Mikael
中科院分区：
文献类型：
--
作者：
Orekhova, Elena V.;Stroganova, Tatiana A.;Elam, Mikael
背景：兴奋/抑制比升高被认为是自闭症的一种机制。皮层兴奋和抑制之间的不平衡可能表现为高频范围的脑电图异常。本研究的目的是探讨β和γ范围脑电图异常是否为自闭症男孩（BWA）的特征。方法：对莫斯科和哥德堡2例3 ~ 8岁的正常发育男孩（TDB）进行持续视觉注意时的脑电图记录。分析高频脑电频谱功率。结果：在两个样本中，BWA在远离肌源性伪影源的电极位置显示出病理性的伽马（24.4-44.0 Hz）活动增加。在这两个样本中，伽马活动的量与BWA发育迟缓程度呈正相关。结论：高频振荡的过量可能反映了皮层兴奋-抑制稳态的失衡。鉴于高频脑电图节律在感知和认知过程中的重要作用，产生高频脑电图节律的神经元机制的早期和可能由遗传决定的异常可能有助于该疾病的发展。需要进一步的研究来调查这些发现对自闭症的特异性。
Background: An elevated excitation/inhibition ratio has been suggested as one mechanism underpinning autism. An imbalance between cortical excitation and inhibition may manifest itself in electroencephalogram (EEG) abnormalities in the high frequency range. The aim of this study was to investigate whether beta and gamma range EEG abnormalities are characteristic for young boys with autism (BWA).Methods: EEG was recorded during sustained visual attention in two independent samples of BWA from Moscow and Gothenburg, aged 3 to 8 years, and in age matched typically developing boys (TDB). High frequency EEG spectral power was analyzed.Results: In both samples, BWA demonstrated a pathological increase of gamma (24.4-44.0 Hz) activity at the electrode locations distant from the sources of myogenic artefacts. In both samples, the amount of gamma activity correlated positively with degree of developmental delay in BWA.Conclusions: The excess of high frequency oscillations may reflect imbalance in the excitation-inhibition homeostasis in the cortex. Given the important role of high frequency EEG rhythms for perceptual and cognitive processes, early and probably genetically determined abnormalities in the neuronal mechanisms generating high frequency EEG rhythms may contribute to development of the disorder. Further studies are needed to investigate the specificity of the findings for autism.