High-resolution optical functional mapping of the human somatosensory cortex.
High-resolution optical functional mapping of the human somatosensory cortex.
复制标题
DOI：
10.3389/fnene.2010.00012
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Obrig, Hellmuth
中科院分区：
文献类型：
--
作者：
Koch, Stefan P;Habermehl, Christina;Obrig, Hellmuth
脑功能的非侵入性光学成像已经在许多领域得到推广，其中功能性磁共振成像（fMRI）由于扫描环境引起的约束而受到限制。除了生理和心理研究，床边监测和神经康复可能是相关的临床应用，但很少探索。在临床研究中推广该工具的一个主要障碍是空间分辨率不足。基于多距离高密度光学成像装置，我们在这里展示了该方法的灵敏度的显着增加。我们表明，光学成像允许在初级体感皮层（SI）的单指代表激活之间的差异。方法上，我们的研究结果证实了Zeff等人（2007）的开创性研究结果，并将其扩展到SI的homuncular组织。在完成一项运动任务后，8名受试者接受了小指和拇指的振动触觉刺激。我们使用了高密度的扩散光学传感阵列结合光学层析重建。光学成像揭示了三个离散的激活焦点，一个用于电机，两个离散的焦点分别用于第一和第五指的振动触觉刺激。将结果与个体解剖学脑解剖结构（MRI）进行配准，这证实了4名受试者的预期皮质脑回定位。空间分辨率的这一进步为光学成像在可塑性研究中的应用开辟了新的前景，特别是在接受神经康复治疗的患者中。
Non-invasive optical imaging of brain function has been promoted in a number of fields in which functional magnetic resonance imaging (fMRI) is limited due to constraints induced by the scanning environment. Beyond physiological and psychological research, bedside monitoring and neurorehabilitation may be relevant clinical applications that are yet little explored. A major obstacle to advocate the tool in clinical research is insufficient spatial resolution. Based on a multi-distance high-density optical imaging setup, we here demonstrate a dramatic increase in sensitivity of the method. We show that optical imaging allows for the differentiation between activations of single finger representations in the primary somatosensory cortex (SI). Methodologically our findings confirm results in a pioneering study by Zeff et al. (2007) and extend them to the homuncular organization of SI. After performing a motor task, eight subjects underwent vibrotactile stimulation of the little finger and the thumb. We used a high-density diffuse-optical sensing array in conjunction with optical tomographic reconstruction. Optical imaging disclosed three discrete activation foci one for motor and two discrete foci for vibrotactile stimulation of the first and fifth finger, respectively. The results were co-registered to the individual anatomical brain anatomy (MRI) which confirmed the localization in the expected cortical gyri in four subjects. This advance in spatial resolution opens new perspectives to apply optical imaging in the research on plasticity notably in patients undergoing neurorehabilitation.