Multishot diffusion-prepared magnitude-stabilized balanced steady-state free precession sequence for distortion-free diffusion imaging
Multishot diffusion-prepared magnitude-stabilized balanced steady-state free precession sequence for distortion-free diffusion imaging
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DOI：
10.1002/mrm.27565
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发表时间：
2019-04-01
影响因子：
3.3
通讯作者：
Hu, Peng
中科院分区：
文献类型：
--
作者：
Gao, Yu;Han, Fei;Hu, Peng
目的：为了开发和评估一种多激发扩散准备（DP）的幅度稳定的平衡稳态自由进动（bSSFP）扩散成像序列与改进的几何fidelity.Methods：一个信号扰流器（幅度稳定器; MS）中实施的DP-bSSFP扩散序列。使用Bloch仿真模拟了幅度稳定器对相位误差的影响。进行了体模研究，以比较表观扩散系数（ADC）的准确性和几何可靠性，使用目标配准误差（TRE）量化，与扩散加权单次激发回波平面成像（DW-ssEPI）。招募了6名志愿者。在B = 500 s/mm（2）条件下，以单次激发方式采集DW-ssEPI、有和无ECG触发的DP-bSSFP以及有和无ECG触发的DP-MS-bSSFP 10次，以评价幅度变异性。结果：仿真结果表明，DP-MS-bSSFP方法对相位误差不敏感。DP-MS-bSSFP方法在体模上具有令人满意的ADC精度，
Purpose: To develop and evaluate a multishot diffusion-prepared (DP) magnitude-stabilized balanced steady-state free precession (bSSFP) diffusion imaging sequence with improved geometric fidelity.Methods: A signal spoiler (magnitude stabilizer; MS) was implemented in a DP-bSSFP diffusion sequence. Effects of magnitude stabilizers with respect to phase errors were simulated using Bloch simulation. Phantom study was conducted to compare the apparent diffusion coefficient (ADC) accuracy and geometric reliability, quantified using target registration error (TRE), with diffusion-weighted single-shot echo-planar imaging (DW-ssEPI). Six volunteers were recruited. DW-ssEPI, DP-bSSFP with and without ECG triggering, and DP-MS-bSSFP with and without ECG triggering were acquired 10 times with b = 500 s/mm(2) in a single-shot manner to evaluate magnitude variability. Diffusion trace images and diffusion tensor images were acquired using a 4-shot DP-MS-bSSFP.Results: Simulation showed that the DP-MS-bSSFP approach is insensitive to phase errors. The DP-MS-bSSFP approach had satisfactory ADC accuracy on the phantom with