PHASIC AND STATIC EXCITABILITY OF TOUCH RECEPTORS IN TOAD SKIN.
PHASIC AND STATIC EXCITABILITY OF TOUCH RECEPTORS IN TOAD SKIN.
复制标题
蟾蜍皮肤中触觉感受器的相位和静态兴奋性。
DOI：
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发表时间：
1963
期刊：
影响因子：
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通讯作者：
U. Lindblom
中科院分区：
文献类型：
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作者：
U. Lindblom
本文研究了蟾蜍在缓慢递增和静态形变过程中触觉感受器的兴奋性。将线性上升和平台相的分级机械刺激与bricf suprimposrd测试脉冲一起施加于原位单个受体。从背根的传入纤维记录动作电位。
在运动刺激阶段，兴奋性迅速上升，然后显示出峰值或平滑平坦（图4）。当刺激进入平台期时，兴奋性突然下降，但兴奋性升高的残余物仍保持静止状态（图5、6），适应速度较慢的受体甚至在平台期出现放电。这种放电的脉冲频率随变形幅度线性上升（图9），但最大频率低于动态放电。虽然静态兴奋性变化和平台放电与变形幅度有关，但动态兴奋性变化与动态放电一样（Lindblom 19621），取决于变形速率。
一个假设，可能有两种机制-一个阶段和一个静态-在一个和相同的受体进行了讨论。动态兴奋性的过程解释了在不同的变形率下刺激后放电的潜伏期变化，并且也可以解释在恒定变形率下的规则放电（Lindelom 1962）。特征性快速适应最好解释为由于在静态刺激期间缺乏激励。
The excitability of the toad's touch receptors was studied during slowly increasing and static deformation. Graded mechanical stimuli of a linearly rising and a platcau phase were applied to single receptors in situ together with bricf suprrimposrd test pulses. Action potentials were recorded from the afferent fiber in the dorsal root.
In the moving stimulus phase, the excitability rose rapidly and then displayed either a peak or a smooth flattening (Fig. 4). As the plateau phase of the stimulation set in, the excitability suddenly fell but a residue of raised excitability persisted statically (Fig. 5, 6).The less rapidly adapting receptors even presented a discharge in the plateau phase. The impulse frequency of this discharge rose linearly with the deformation amplitude (Fig. 9) but the maximum frequency was low as compared with that in the dynamic discharge. While the static excitability change and the plateau discharge were related to the amplitude of deformation, the dynamic excitability change, like the dynamic discharge (Lindblom 19621, depended on the rate of deformation.
An hypothesis that there may be two mechanisms — one phasic and one static —in one and the same receptor is discussed. the course of the dynamic excitability explains the latency variations of the dischargr following stimulation at varying deformation rates, and may also account for the regular firing at constant deformation rate (Lindelom 1962). The characteristic rapid adaption is best explained as due to lack of excitation during static stimulation.