SUPPRESSION OF CEREBELLAR PURKINJE-CELLS DURING CONDITIONED-RESPONSES IN FERRETS
SUPPRESSION OF CEREBELLAR PURKINJE-CELLS DURING CONDITIONED-RESPONSES IN FERRETS
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DOI：
10.1097/00001756-199401000-00030
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发表时间：
1994-01-31
期刊：
影响因子：
1.7
通讯作者：
IVARSSON, M
中科院分区：
文献类型：
--
作者：
HESSLOW, G;IVARSSON, M
条件反射雪貂，使用电刺激前肢作为条件刺激和眶周刺激作为非条件刺激，直到它们产生条件眨眼反应。这些的潜伏期为125-250 ms。微电极记录由单个浦肯野细胞在小脑皮质的C3区的眨眼控制区。而动物的浦肯野细胞，只收到不成对的刺激介绍，反应微弱或根本没有条件刺激，在条件动物的一些细胞反应与简单的尖峰放电的强大抑制。这种抑制的潜伏期为50-200毫秒。结果支持这一假设，经典条件反射涉及小脑浦肯野细胞的可塑性变化。
DECEREBRATE ferrets were conditioned, using electrical stimulation of the forelimb as conditioned stimulus and periorbital stimulation as unconditioned stimulus, until they produced conditioned eyeblink responses. The latency of these was 125-250 ms. Microelectrode recordings were made from single Purkinje cells in an eyeblink controlling area in the c3 zone of the cerebellar cortex. Whereas Purkinje cells in animals, which had only received unpaired stimulus presentations, responded weakly or not at all to the conditioned stimulus, some cells in conditioned animals responded with a powerful suppression of simple spike firing. The latency of this suppression was 50-200 ms. The results support the hypothesis that classical conditioning involves plastic changes in cerebellar Purkinje cells.