Topographic Maps within Brodmann's Area 5 of macaque monkeys.
Topographic Maps within Brodmann's Area 5 of macaque monkeys.
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DOI：
10.1093/cercor/bhr257
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发表时间：
2012-08
期刊：
影响因子：
3.7
通讯作者：
A. Seelke;Jeffrey Padberg;E. Disbrow;Shawn M. Purnell;G. Recanzone;L. Krubitzer
中科院分区：
文献类型：
--
作者：
A. Seelke;Jeffrey Padberg;E. Disbrow;Shawn M. Purnell;G. Recanzone;L. Krubitzer
布罗德曼区 5 传统上包括顶内沟 (IPS) 的喙侧岸以及中央后回和内侧壁的后部。然而，这个大的建筑区域的不同部分可能具有与到达和抓握行为相关的不同功能。目前的研究使用多单元记录技术对麻醉的猕猴进行了大范围的IPS吻侧库的调查，以便可以使用数百个记录位点来确定该区域皮质区域的功能细分和地形组织。我们在 IPS 嘴侧确定了一个侧面区域，我们称之为区域 5L。 5L 区包含的神经元的感受野主要集中在肩部、前肢和手指上，没有明显的其他身体部位的表征。因此，前肢有很大的放大倍数。该区域神经元的感受野通常包含前肢的多个关节或多个手指，这会导致地图组织中的地形不精确或断裂。我们的结果提供了在个体猕猴中获得的第一个 5L 区域的整体地形图，并表明该区域与 IPS 的更内侧部分不同。
Brodmann's area 5 has traditionally included the rostral bank of the intraparietal sulcus (IPS) as well as posterior portions of the postcentral gyrus and medial wall. However, different portions of this large architectonic zone may serve different functions related to reaching and grasping behaviors. The current study used multiunit recording techniques in anesthetized macaque monkeys to survey a large extent of the rostral bank of the IPS so that hundreds of recording sites could be used to determine the functional subdivisions and topographic organization of cortical areas in this region. We identified a lateral area on the rostral IPS that we term area 5L. Area 5L contains neurons with receptive fields on mostly the shoulder, forelimb, and digits, with no apparent representation of other body parts. Thus, there is a large magnification of the forelimb. Receptive fields for neurons in this region often contain multiple joints of the forelimb or multiple digits, which results in imprecise topography or fractures in map organization. Our results provide the first overall topographic map of area 5L obtained in individual macaque monkeys and suggest that this region is distinct from more medial portions of the IPS.