The Multiple Roles of ATP-Gated P2(X) Ion Channels in T Lymphocytes
The Multiple Roles of ATP-Gated P2(X) Ion Channels in T Lymphocytes
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T 淋巴细胞中 ATP 门控 P2(X) 离子通道的多重作用
DOI：
10.1166/msr.2015.1046
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Koch-Nolte F
中科院分区：
文献类型：
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作者：
Haag F;Menzel S;Javed S;Rissiek A;Adriouch S;Tolosa E;Koch-Nolte F
细胞外嘌呤核苷酸如ATP及其衍生物在调节T淋巴细胞功能中起重要作用。P2X受体是ATP门控阳离子通道，允许钙和钠流入细胞，钾流出细胞。近年来积累的证据表明，P2X受体通过增加细胞内的胞质钙水平，在T细胞受体（TCR）连接后积极地增强T淋巴细胞的活化。尽管这一概念已被广泛接受，但P2X受体促进TCR信号传导的确切机制仍不清楚。本文综述了P2X受体对T淋巴细胞亚群发育和功能的影响，特别是其在TCR信号转导中的作用。
Extracellular purine nucleotides such as ATP and its derivatives play important roles in the modulation of T lymphocyte functions. P2X receptors are ATP-gated cation channels that permit the influx of calcium and sodium into and the efflux of potassium out of the cell. In recent years evidence has accumulated that P2X receptors positively reinforce the activation of T lymphocytes upon T cell receptor (TCR) ligation by increasing cytosolic calcium levels within the cell. Although this concept has gained wide acceptance, the precise mechanisms by which P2X receptors contribute to TCR signaling remain unclear. This review summarizes current knowledge about the effects of P2X receptors on the development and functions of T lymphocyte subsets, and focuses especially on their role in the context of TCR signaling.