Facile Synthesis of Spinel-Type Copper Cobaltite Nanoplates for Enhanced Electrocatalytic Detection of Acetylcholine
Facile Synthesis of Spinel-Type Copper Cobaltite Nanoplates for Enhanced Electrocatalytic Detection of Acetylcholine
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DOI：
10.1021/acssuschemeng.8b06021
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发表时间：
2019-04-15
影响因子：
8.4
通讯作者：
Chen, Tse-Wei
中科院分区：
文献类型：
--
作者：
Balasubramanian, Paramasivam;Balamurugan, T. S. T.;Chen, Tse-Wei
在此，我们报告了新的尖晶石型CuCo 2 O 4纳米片（CCO NPs）的制备通过一个具有成本效益的，软模板（柠檬酸盐）辅助的方法，然后通过低温煅烧。在合成过程中，金属阳离子如Cu 2+和Co 2+可以通过配位相互作用与柠檬酸盐分子反应以在高温下形成CuCo-柠檬酸盐。在500 ℃的煅烧过程中，柠檬酸盐分子通过简单的有机物种从CuCo-柠檬酸盐前体中消除，从而成功地形成尖晶石型CuCo 2 O 4纳米片。通过透射电子显微镜（TEM）、X射线衍射（XRD）和X射线光电子显微镜（XPS）评估合成的CCO NP的表面形态、结晶性质和相纯度。合成的CuCo 2 O 4纳米片被用来构建一个敏感和可靠的无酶的乙酰胆碱（ACh）的电化学传感器，显示了有意义的检测限（30 nM）与广泛的动态范围（0.2-3500 μ M），涵盖临床范围的ACh。此外，开发的ACh传感器具有长期耐用性和良好的重现性。ACh传感器的床旁实用性在加标血清样品中得到了证明，回收率可接受。本工作展示了一种简便的合成方法，具有广泛的潜力，朝着制备二元过渡金属氧化物（BTMOs）不同的电催化应用。
Herein, we report the preparation of novel spinel-type CuCo2O4 nanoplates (CCO NPs) through a cost-effective, soft-template (citrate)-assisted method, followed by low-temperature calcination. In the synthesis process, the metal cations such as Cu2+ and Co2+ can react with citrate molecules via coordination interaction to form the CuCo-citrate at elevated temperature. During the calcination process at 500 degrees C, the citrate molecules were eliminated from the CuCo-citrate precursor via simple organic species, and thus, spinel-type CuCo2O4 nanoplates were formed successfully. Surface morphology, crystalline nature, and phase purity of as-synthesized CCO NPs were assessed by transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron microscopy (XPS). As-synthesized CuCo2O4 nanoplates were used to construct a sensitive and reliable enzyme-free electrochemical sensor of acetylcholine (ACh) that shows a meaningful limit of detection (30 nM) with broad dynamic range (0.2-3500 mu M) covering the clinical range of ACh. Furthermore, the developed ACh sensor delivered long-term durability and good reproducibility. The point-of-care utility of the ACh sensor was demonstrated in spiked blood serum samples with acceptable recovery rates. The present work demonstrates a facile synthesis method with an extensive potential toward the preparation of binary transition metal oxides (BTMOs) for divergent electrocatalytic applications.