Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement.
Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement.
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DOI：
10.1039/c5cc07780j
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发表时间：
2016-01-04
期刊：
影响因子：
--
通讯作者：
Doyle MP
中科院分区：
文献类型：
--
作者：
Sha Q;Arman H;Doyle MP
以2，3-二酮酯为原料，经两步不对称合成了1H-吡咯-3（2 H）-酮衍生物，ee值为99%。
An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2, 3-diketoesters has been developed.