Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System
Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System
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DOI：
10.1007/400_2008_3
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Sakano, H.
中科院分区：
文献类型：
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作者：
Imai, T.;Sakano, H.
在小鼠嗅觉系统中，每个嗅觉感觉神经元（OSN）以单等位基因方式表达约1，000个中的单一类型的气味受体（OR）。此外，表达相同OR的OSN将它们的轴突会聚到嗅球上的一组特定的肾小球。这两个基本原则是外周嗅觉系统的基础，并由表达的OR蛋白本身调节。单一OR基因的选择是通过随机增强子-启动子相互作用和OR蛋白负反馈调节的组合来确保的。在轴突投射中，OR衍生的环AMP信号和神经元活性决定轴突引导/分选分子的表达水平，从而指导肾小球定位和轴突分选。
In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer-promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/sorting molecules, and thereby direct glomerular positioning and axon sorting.