RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway.
RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway.
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DOI：
10.3390/ijms17060985
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发表时间：
2016-06-22
影响因子：
5.6
通讯作者：
Ceman S
中科院分区：
文献类型：
--
作者：
Kenny P;Ceman S
MicroRNA 通过转录后调节 30%–60% 的哺乳动物基因组的基因表达来发挥作用。 MicroRNA 是所有细胞过程中的关键调节因子，但细胞激活或抑制 microRNA 介导的翻译调节的机制尚不清楚。在这篇综述中，我们讨论了 RNA 结合蛋白脆性 X 智力迟钝蛋白 (FMRP) 及其在 microRNA 介导的翻译调控中的作用。从历史上看，FMRP 被认为是一种翻译抑制因子。然而，新出现的数据表明，FMRP 在调节 microRNA 介导的翻译抑制中既具有激动作用，又具有拮抗作用。这种双功能作用取决于 FMRP 与 RNA 解旋酶莫洛尼白血病病毒 10 (MOV10) 的相互作用，后者会改变结合 mRNA 的结构景观，从而促进或抑制其与 RNA 诱导沉默复合物的关联。
MicroRNAs act by post-transcriptionally regulating the gene expression of 30%–60% of mammalian genomes. MicroRNAs are key regulators in all cellular processes, though the mechanism by which the cell activates or represses microRNA-mediated translational regulation is poorly understood. In this review, we discuss the RNA binding protein Fragile X Mental Retardation Protein (FMRP) and its role in microRNA-mediated translational regulation. Historically, FMRP is known to function as a translational suppressor. However, emerging data suggests that FMRP has both an agonistic and antagonistic role in regulating microRNA-mediated translational suppression. This bi-functional role is dependent on FMRP’s interaction with the RNA helicase Moloney leukemia virus 10 (MOV10), which modifies the structural landscape of bound mRNA, therefore facilitating or inhibiting its association with the RNA-Induced Silencing Complex.