Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer
Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer
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DOI：
10.1021/acs.nanolett.6b02547
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发表时间：
2016-10-01
期刊：
影响因子：
10.8
通讯作者：
Park, Jae Hyung
中科院分区：
文献类型：
--
作者：
Deepagan, V. G.;You, Dong Gil;Park, Jae Hyung
虽然声动力疗法（SDT）已成为传统光动力疗法的潜在替代方案，但诸如TiO 2纳米颗粒（NP）的声致敏剂的低量子产率仍然是一个主要问题。在这里，我们已经开发了纳米复合材料（HAu-TiO 2 NC）作为声敏剂，以改善SDT。对HAu-TiO 2纳米粒子的物理化学性质进行了深入研究，并与没有金沉积的纳米粒子进行了比较。当HAu-TiO 2 NC暴露于超声波时，产生大量的活性氧（ROS），导致在体内全身施用后完全抑制肿瘤生长。总的来说，很明显，金与TiO 2纳米颗粒的复合物显著增加了ROS产生的水平，这意味着它们作为SDT药物用于癌症治疗的潜力。
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photo dynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nano composites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasoUnd, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for Cancer therapy.