The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae
The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae
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DOI：
10.1111/j.1574-6968.1998.tb12993.x
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发表时间：
1998-05-01
影响因子：
2.1
通讯作者：
Nombela, C
中科院分区：
文献类型：
--
作者：
Rodriguez-Peña, JM;Cid, VJ;Nombela, C
我们报道了一个酿酒酵母基因的发现，该基因是在以D-木酮糖为唯一碳源的培养基中生长所必需的。该基因对应于我们先前描述的YGR 194 c开放阅读框架，现在将其重命名为XKS 1。XKS 1基因编码的蛋白质的数据库比较显示与不同的木酮糖激酶具有显着的同源性，表明可能在木酮糖磷酸化中起作用。着丝粒质粒中的野生型基因补充了xks 1 S的缺陷生长。酿酒酵母突变株木酮糖。相比之下，过表达对这种碳源中的细胞生长产生负面影响。(C)1998年，欧洲微生物学会联合会。出版社：Elsevier Science B. V.
We report the finding of a Saccharomyces cerevisiae gene necessary for growth ill culture media with D-xylulose as the sole carbon source. This gene corresponds to the YGR194c open reading frame that we have previously described, and it is renamed now XKS1. Data bank comparisons of the protein encoded by the XKS1 gene showed significant homology with different xylulokinases, indicating a possible role in xylulose phosphorylation. The wild-type gene in a centromeric plasmid complemented defective growth of xks1 S. cerevisiae mutant strains in xylulose. By contrast, overexpression negatively influenced cell growth in this carbon source. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.