Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype.
Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype.
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DOI：
10.1155/2015/634865
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发表时间：
2015
影响因子：
--
通讯作者：
Lorico A
中科院分区：
文献类型：
--
作者：
Green TM;Alpaugh ML;Barsky SH;Rappa G;Lorico A
细胞外囊泡（EV）在癌症进展中的研究是一个复杂且快速发展的领域。癌症中的细胞相互作用的整个类别最初被假定为仅归因于可溶性分泌分子，现在已经演变为包括膜封闭的细胞外囊泡（EV），其包括外来体和脱落的微囊泡（MV），并且可以含有许多与以可溶性形式分泌的那些相同的分子，但也含有许多不同的分子。癌细胞释放的EV可以以自分泌和旁分泌的方式将mRNA、miRNA和蛋白质转移到肿瘤微环境中的不同受体细胞，对信号通路、mRNA转录和蛋白质表达产生显着影响。EV向靶细胞的转移反过来又支持癌症生长、免疫抑制和转移形成。这篇综述专门关注乳腺癌EV，重点是乳腺癌衍生的外泌体，请记住乳腺癌衍生的EV与其他癌症的EV具有一些共同的物理特性。
The study of extracellular vesicles (EVs) in cancer progression is a complex and rapidly evolving field. Whole categories of cellular interactions in cancer which were originally presumed to be due solely to soluble secreted molecules have now evolved to include membrane-enclosed extracellular vesicles (EVs), which include both exosomes and shed microvesicles (MVs), and can contain many of the same molecules as those secreted in soluble form but many different molecules as well. EVs released by cancer cells can transfer mRNA, miRNA, and proteins to different recipient cells within the tumor microenvironment, in both an autocrine and paracrine manner, causing a significant impact on signaling pathways, mRNA transcription, and protein expression. The transfer of EVs to target cells, in turn, supports cancer growth, immunosuppression, and metastasis formation. This review focuses exclusively on breast cancer EVs with an emphasis on breast cancer-derived exosomes, keeping in mind that breast cancer-derived EVs share some common physical properties with EVs of other cancers.