Depression in multiple sclerosis: A longitudinal analysis
Depression in multiple sclerosis: A longitudinal analysis
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DOI：
10.1016/j.apnu.2007.02.008
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发表时间：
2007-08-01
影响因子：
2.3
通讯作者：
Brown, Adarna
中科院分区：
文献类型：
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作者：
Beal, Claudia C.;Stuifbergen, Alexa K.;Brown, Adarna
多发性硬化症（MS）患者的抑郁症发病率很高，但很少有研究对抑郁症进行长期调查。该分析考虑了607名MS患者在7年期间的数据，作为慢性疾病患者生活质量的持续纵向研究的一部分。使用潜在生长曲线分析来检查抑郁症的轨迹以及协变量（如年龄、MS诊断时间、MS类型和功能限制）对研究期间抑郁症变化程度的影响。分析结果表明，个体的抑郁症状随着时间的推移而波动，但总体上没有显示出群体整体显著增加或减少的趋势。年龄较小、MS诊断时间较长、MS的进行性形式和更大程度的功能限制在时间1时预示着更严重的抑郁症状。除了功能限制在所有时期都与抑郁有关外，这些变量并不能预测抑郁症状随时间的变化。性别并不是抑郁症状变化的重要预测因素，女性患抑郁症的比例也没有像之前的研究预期的那样高。该分析的结果表明，对所有多发性硬化症患者进行抑郁症筛查的重要性(c) 2007 Elsevier Inc.。版权所有。
High rates of depression have been documented in persons with multiple sclerosis (MS), but few studies have examined depression over time. This analysis considered data from 607 persons with MS in a 7-year period as part of an ongoing longitudinal study of quality of life in chronic illness. Latent growth curve analysis was used to examine trajectories in depression and the effects of covariates such as age, time since diagnosis of MS, type of MS, and functional limitations on the extent to which depression changed in the study period. Results of the analysis indicated that depressive symptoms fluctuated over time for individuals but did not show a tendency to an overall significant increase or decrease for the group as a whole. Younger age, longer time since diagnosis of MS, progressive forms of MS, and greater extent of functional limitation were predictive of greater depressive symptoms atTime 1.With the exception of functional limitation, which showed an association with depression at all periods, these variables did not predict changes in depressive symptoms over time. Gender was not a significant predictor of changes in depressive symptoms, nor did women have higher rates of depression as expected from previous research. The results of this analysis indicate the importance of screening for depression in all persons with MS. (c) 2007 Elsevier Inc. All rights reserved.