DNA methyltransferases and their roles in tumorigenesis.
DNA methyltransferases and their roles in tumorigenesis.
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DNA甲基转移酶及其在肿瘤发生中的作用
DOI：
10.1186/s40364-017-0081-z
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发表时间：
2017
影响因子：
11.1
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Zhang W;Xu J
DNA甲基化在基因表达、染色质稳定性和遗传印迹中起着重要作用。在哺乳动物中，DNA甲基化模式由DNA甲基转移酶（dnmt）书写和调控，包括DNMT1、DNMT3A和DNMT3B。最近出现的证据表明，DNMT的缺陷参与肿瘤的转化和进展，从而表明由DNMT异常引起的表观遗传破坏与肿瘤发生有关。在此，我们回顾了与癌细胞中DNMT改变相关的最新发现，并讨论了这些影响对致癌表型的贡献。
DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are involved in tumor transformation and progression, thus indicating that epigenetic disruptions caused by DNMT abnormalities are associated with tumorigenesis. Herein, we review the latest findings related to DNMT alterations in cancer cells and discuss the contributions of these effects to oncogenic phenotypes.