Decreased β-cell proliferation impairs the adaptation to pregnancy in rats malnourished during perinatal life
Decreased β-cell proliferation impairs the adaptation to pregnancy in rats malnourished during perinatal life
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DOI：
10.1677/joe.0.1740215
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发表时间：
2002-08-01
影响因子：
4
通讯作者：
Bréant, B
中科院分区：
文献类型：
--
作者：
Avril, I;Blondeau, B;Bréant, B
我们研究了负责8个月大的（PM）女性无法在怀孕期间适应其β细胞质量的细胞机制。研究了β细胞分数，大小和增殖的怀孕期间的演变。与对照女性相比，在怀孕的第21天，Beta细胞分数的增加小于对照女性。两组怀孕期间都观察到轻微的β细胞肥大。在对照女性中，β细胞5-溴-2'-脱氧尿苷（BRDU）标记指数（li）从怀孕前的0.07 +/- 0.04％增加到第12天的1.13 +/- 0.20％，此后下降，此后降低，在第21天达到了Beta-cell Pluper Fliperifer at day 12（0.10）的基础水平。
We investigated the cellular mechanisms responsible for the inability of 8-month-old previously malnourished (PM) females to adapt their beta-cell mass during pregnancy. The evolution during pregnancy of beta-cell fraction, size and proliferation was studied. At day 21 of pregnancy beta-cell fraction increased less in PM than in control females, compared with their non-pregnant values. A slight beta-cell hypertrophy was observed during pregnancy in both groups. In control females, beta-cell 5-bromo-2'-deoxyuridine (BrdU) labelling index (LI) increased from 0.07 +/- 0.04% before pregnancy to 1.13 +/- 0.20% at day 12 and decreased thereafter to reach again basal levels at day 21. In PM females, beta-cell proliferation rate was decreased at day 12 (0.74 +/- 0.15%, P