Autoradiographic localization of estradiol-concentrating cells in the female hamster brain.
Autoradiographic localization of estradiol-concentrating cells in the female hamster brain.
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雌性仓鼠大脑中雌二醇浓缩细胞的放射自显影定位。
DOI：
10.1159/000122626
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发表时间：
1976
影响因子：
4.1
通讯作者：
D. Pfaff
中科院分区：
文献类型：
--
作者：
M. S. Krieger;J. Morrell;D. Pfaff
用放射自显影方法对雌性仓鼠脑内雌激素聚集细胞的定位进行了研究。在下丘脑，后内侧视前区(MPOA)、下丘脑前部(AHA)、腹内侧核(Vm)、弓状核(ARC)和乳头体前腹核(VPM)均有标记细胞。在边缘系统，腹外侧隔、终纹床核、杏仁内侧核和皮质核均有标记细胞。在中脑中央灰质(CG)、下丘脑外侧核、下丘脑下丘脑底核和内嗅皮质也可见少量标记细胞。仓鼠体内集中雌激素的细胞的神经解剖学模式支持广义脊椎动物模式的概念。此外，对仓鼠和大鼠细胞内~H-雌二醇(~H-E_2)浓度模式的比较似乎表明，不同物种对雌激素的反应差异可能与雌激素结合的不同平行。
Autoradiographic methods were used to study the location of estrogen-concentrating cells in the brain of the female hamster. In the hypothalamus, well-labelled cells were reliably found in the posterior medial preoptic area (MPOA), the anterior hypothalamus (AHA), and the ventromedial (VM), arcuate (ARC) and ventral premammillary nuclei (VPM). In the limbic system, well-labelled cells were found in the ventro-lateral septum, bed nucleus of the stria terminalis, and the medial and cortical nuclei of the amygdala. Labelled cells, in small numbers, were also detected in the mesencephalic central gray (CG), lateral hypothalamus, subiculum and entorhinal cortex. The neuroanatomical pattern of estrogen-concentrating cells in the hamster supports the concept of a generalized vertebrate pattern. Furthermore, a comparison of hamster and rat patterns of cellular 3H-estradiol (3H-E2) concentration appears to suggest that species differences in their responsiveness to estrogen may be paralleled by differences in estrogen binding.