Trauma moderates the development of the oscillatory dynamics serving working memory in a sex-specific manner
Trauma moderates the development of the oscillatory dynamics serving working memory in a sex-specific manner
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创伤调节了以性别特异性方式服务于工作记忆的振荡动力学的发展
DOI：
10.1093/cercor/bhac008
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Wilson, Tony W
中科院分区：
文献类型：
--
作者：
Killanin, Abraham D;Embury, Christine M;Picci, Giorgia;Heinrichs-Graham, Elizabeth;Wang, Yu-Ping;Calhoun, Vince D;Stephen, Julia M;Wilson, Tony W
工作记忆是一种更高层次的认知过程，支持日常生活的许多方面。工作记忆是将物品保存在记忆库中以供进一步操作的能力。童年创伤与认知发展的改变有关，包括言语工作记忆(VWM)的特殊缺陷，但其神经基础仍鲜为人知。脑磁图(MEG)对VWM的研究可靠地表明，在编码过程中，左侧语言区域的α活动减少，而在维持期，顶枕叶皮质的α活动增加。在这项研究中，我们在一组9到15岁的年轻人中研究了童年创伤是否影响行为表现和使用MEG的VWM服务的振荡动力学。所有参与者都完成了加州大学洛杉矶分校创伤历史档案的修订版，然后在MEG期间执行了VWM任务。我们的发现表明，性别与年龄、创伤与年龄之间存在三向互动，经历较高程度创伤的年轻女性的准确度得分最低，且与年龄呈最强的正相关(即年龄越大表现越好)。同样，童年创伤程度较高的女性在右侧颞叶和顶叶皮质的维持期表现出与年龄相关的阿尔法变化。这些发现表明，创伤暴露可能会以一种性别特有的方式改变服务于VWM处理的神经振荡的发展轨迹。
Working memory, the ability to hold items in memory stores for further manipulation, is a higher order cognitive process that supports many aspects of daily life. Childhood trauma has been associated with altered cognitive development including particular deficits in verbal working memory (VWM), but the neural underpinnings remain poorly understood. Magnetoencephalography (MEG) studies of VWM have reliably shown decreased alpha activity in left-lateralized language regions during encoding, and increased alpha activity in parieto-occipital cortices during the maintenance phase. In this study, we examined whether childhood trauma affects behavioral performance and the oscillatory dynamics serving VWM using MEG in a cohort of 9- to 15-year-old youth. All participants completed a modified version of the UCLA Trauma History Profile and then performed a VWM task during MEG. Our findings indicated a sex-by-age-by-trauma three-way interaction, whereby younger females experiencing higher levels of trauma had the lowestd’ accuracy scores and the strongest positive correlations with age (i.e. older performed better). Likewise, females with higher levels of childhood trauma exhibited altered age-related alpha changes during the maintenance phase within the right temporal and parietal cortices. These findings suggest that trauma exposure may alter the developmental trajectory of neural oscillations serving VWM processing in a sex-specific way.