The clearance of intravitreal gentamicin.
The clearance of intravitreal gentamicin.
复制标题
玻璃体内庆大霉素的清除率。
DOI：
10.1016/s0002-9394(14)75908-2
复制
发表时间：
1981
影响因子：
4.2
通讯作者：
R. Forster
中科院分区：
文献类型：
--
作者：
L. Cobo;R. Forster
玻璃体内注射庆大霉素在无炎症的无晶状体兔眼中的清除速度明显快于无晶状体对照组，前者的半衰期为12小时，后者为32小时。在无晶状体眼和实验性金黄色葡萄球菌性眼炎的无晶状体眼中也有类似的差异，但没有相同水平的显著性。来自9只接受再注射或玻璃体切除术的无晶状体感染眼睛的人体数据表明，在最初的玻璃体内注射后48小时或更长时间内庆大霉素的治疗水平并不一致。
Intravitreal gentamicin cleared significantly more rapidly from the uninflamed aphakic rabbit eye than the phakic control, with a half-life of 12 hours in the former and 32 hours in the latter. A similar difference was noted in aphakic and phakic eyes with an experimentalStaphylococcus aureusendophthalmitis, but without the same level of significance. Human data from nine aphakic infected eyes undergoing reinjection or vitrectomy indicated that therapeutic levels of gentamicin are not consistently found 48 hours or more after the initial intravitreal injection.