EXTREME DISCORDANT SIB PAIRS FOR MAPPING QUANTITATIVE TRAIT LOCI IN HUMANS
EXTREME DISCORDANT SIB PAIRS FOR MAPPING QUANTITATIVE TRAIT LOCI IN HUMANS
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DOI：
10.1126/science.7777857
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发表时间：
1995-06-16
期刊：
影响因子：
56.9
通讯作者：
ZHANG, HP
中科院分区：
文献类型：
--
作者：
RISCH, N;ZHANG, HP
同胞之间的差异分析（同胞对分析）是一种标准的遗传连锁分析方法，用于定位数量性状基因座，例如人类中导致高血压和肥胖的基因座。在传统的设计中，配对是随机选择的，或者其中一个同胞具有极端的性状值。大多数这样的对提供检测链接的功效很小;只有高值一致的对、低值一致的对或极不一致的对（例如，一个在分布的前10%中，另一个在分布的后10%中）提供显著的功效。专注于不一致的配对可以减少10到40倍的传统设计所需的基因分型量。
Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans. In traditional designs, pairs are selected at random or with one sib having an extreme trait value. The majority of such pairs provide little power to detect linkage; only pairs that are concordant for high values, low values, or extremely discordant pairs (for example, one in the top 10 percent and the other in the bottom 10 percent of the distribution) provide substantial power. Focus on discordant pairs can reduce the amount of genotyping necessary over conventional designs by 10- to 40-fold.