Gonadotropin-Inhibitory Hormone Plays Roles in Stress-Induced Reproductive Dysfunction.
Gonadotropin-Inhibitory Hormone Plays Roles in Stress-Induced Reproductive Dysfunction.
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促性腺激素抑制激素在应激诱导的生殖功能障碍中发挥作用。
DOI：
10.3389/fendo.2017.00062
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发表时间：
2017
影响因子：
5.2
通讯作者：
Irahara M
中科院分区：
文献类型：
--
作者：
Iwasa T;Matsuzaki T;Yano K;Irahara M
身体和心理压力源抑制下丘脑-垂体-性腺轴活动和性行为，从而诱发生殖功能障碍。最近，研究表明，哺乳动物中的促性腺激素抑制激素（GnIH），也称为 RFamide 相关肽 3（RFRP），是促性腺激素释放激素（GnRH）和促性腺激素的有效抑制调节剂，与应激引起的生殖功能障碍有关。 GnIH/Rfrp（编码 RFRP-3 的基因）表达和活性会因心理和免疫应激而增加，并且这种改变会抑制 GnRH 和促性腺激素的分泌。糖皮质激素充当压力与下丘脑 GnIH/RFRP-3 之间相互作用的介质。 GnIH/RFRP-3 在应激引起的性行为抑制和不孕症中也发挥着重要作用，GnIH/Rfrp 基因沉默可以完全恢复性行为和生育能力。这篇综述总结了目前已知的 GnIH 在应激诱发的生殖功能障碍中的作用。
Physical and psychological stressors suppress hypothalamic–pituitary–gonadal axis activity and sexual behavior and consequently induce reproductive dysfunction. Recently, it has been shown that gonadotropin-inhibitory hormone (GnIH), also called RFamide-related peptide 3 (RFRP) in mammals, which is a potent inhibitory regulator of gonadotropin-releasing hormone (GnRH) and gonadotropin, is involved in stress-induced reproductive dysfunction. GnIH/Rfrp (the gene coding RFRP-3) expression and activity are increased by psychological and immune stress, and this alteration suppresses GnRH and gonadotropin secretion. Glucocorticoid acts as a mediator that interacts between stress and hypothalamic GnIH/RFRP-3. GnIH/RFRP-3 also plays important roles in stress-induced suppression of sexual behavior and infertility, and genetic silencing of GnIH/Rfrp completely recovers sexual behavior and fertility. This review summarizes what is currently known about the roles of GnIH in stress-induced reproductive dysfunction.