New approach for assessing vascular distribution within bone tumors using dynamic contrast-enhanced MRI
New approach for assessing vascular distribution within bone tumors using dynamic contrast-enhanced MRI
复制标题
使用动态对比增强 MRI 评估骨肿瘤内血管分布的新方法
DOI：
10.1007/s00432-006-0190-9
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发表时间：
2007
影响因子：
3.6
通讯作者：
T. Ozaki
中科院分区：
文献类型：
--
作者：
Y. Kawakami;T. Kunisada;S. Sugihara;Atsushi Ono;K. Nishida;N. Abe;A. Kawai;K. Fujiwara;Y. Morimoto;T. Ozaki
目的通过动态增强MRI分析骨肿瘤内血管分布，鉴别良恶性骨肿瘤。在每个肿瘤的最大部分内设置七个小的感兴趣区域（ROI）。四个ROI均匀放置在周围，三个ROI均匀放置在肿瘤内最长宽度的线上。在整个肿瘤和每个ROI的时间-强度曲线上计算曲线的斜率（%斜率）。计算ROI的%斜率的方差值以评估肿瘤内每个ROI处的强度变化的分散性。（70.4 ± 60.3%）显著高于良性骨肿瘤（37.6 ± 52.9%）（P = 0.015），尽管巨细胞瘤（GCT），一种局部侵袭性肿瘤，具有相对较高的%斜率。恶性骨肿瘤的%斜率方差均值（3485.9 ± 5942.5）显著高于所有良性骨肿瘤的%斜率方差均值（470.4 ± 583.9）（P = 0.012），表明恶性骨肿瘤内7个感兴趣区的%斜率值较良性骨肿瘤内的感兴趣区变化更大。GCT也表现出较低的value. ConclusionWe的方法，分析信号强度的变化在七个独立的区域，评估肿瘤内的血管分布可能是一个有用的工具，用于区分良性和恶性骨肿瘤。
PurposeTo differentiate benign from malignant bone tumors by analyzing the vascular distribution within bone tumors with dynamic contrast-enhanced MRI.MethodsWe studied dynamic contrast-enhanced MRI for 49 bone tumors (22 malignant and 27 benign tumors). Seven small regions of interest (ROI) were set inside the largest portion of each tumor. Four ROI were placed evenly on the periphery and three ROI were placed evenly on the line of the longest breadth within the tumor. The slope of the curve (%Slope) was calculated on the time–intensity curves of the whole tumor and of each ROI. The variance values for the %Slope of the ROI were calculated to assess the dispersion of the intensity change at each ROI within the tumor.ResultsMean value of the %Slopes of whole tumor regions for malignant bone tumors (70.4 ± 60.3%) was significantly higher than that for benign bone tumors (37.6 ± 52.9%) (P = 0.015), although giant cell tumor (GCT), a locally aggressive tumor, had a relatively higher %Slope. Mean value of the variance of %Slopes for malignant bone tumors (3485.9 ± 5942.5) was significantly higher than that for all benign tumors (470.4 ± 583.9) (P = 0.012), indicating that the %Slope values of seven ROI within malignant bone tumors varied more widely compared with the ROI inside benign bone tumors. GCT also demonstrated a lower value.ConclusionOur method of analyzing the signal intensity change at seven separate regions that evaluates the vascular distribution within a tumor could be a useful tool for differentiating between benign and malignant bone tumors.