Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study).
Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study).
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DOI：
10.3389/fgene.2011.00056
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发表时间：
2011
影响因子：
3.7
通讯作者：
Chung WK
中科院分区：
文献类型：
--
作者：
Tiwari HK;Patki A;Lieberman J;Stroup TS;Allison DB;Leibel RL;Chung WK
抗精神病药物广泛用于治疗精神分裂症、双相情感障碍和其他精神疾病。尽管这些药物具有治疗优势，但其中许多药物会大幅增加体重。我们评估了在临床抗精神病药物试验中接受特定抗精神病药物治疗的患者中与体重调节有关的31个基因的等位基因与体重增加的相关性，在干预有效性研究中，我们发现钾通道抑制整流亚家族J成员11（KCNJ11）中的rs2237988，溶质携带者家族30成员8（SLC30A8）中的rs13269119和脂肪量和肥胖相关（FTO）中的rs9922047与体重增加百分比相关。我们还观察到rs11643744与给药对体重增加的显著相互作用。
Antipsychotic drugs are widely used in treating schizophrenia, bipolar disorder, and other psychiatric disorders. Many of these drugs, despite their therapeutic advantages, substantially increase body weight. We assessed the association of alleles of 31 genes implicated in body weight regulation with weight gain among patients being treated with specific antipsychotic medications in the clinical antipsychotic trials in intervention effectiveness study, we found that rs2237988 in Potassium Channel Inwardly Rectifying Subfamily J Member 11 (KCNJ11), rs13269119 in Solute carrier family 30 member 8 (SLC30A8), and rs9922047 in fat mass and obesity associated (FTO) were associated with percent weight gain. We also observed the significant interaction of rs11643744 by treatment effect on the weight gain.