FOCAL LYMPHOCYTIC MYOCARDITIS IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) - A CORRELATIVE MORPHOLOGIC AND CLINICAL-STUDY IN 26 CONSECUTIVE FATAL CASES
FOCAL LYMPHOCYTIC MYOCARDITIS IN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) - A CORRELATIVE MORPHOLOGIC AND CLINICAL-STUDY IN 26 CONSECUTIVE FATAL CASES
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DOI：
10.1016/0735-1097(88)90420-2
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发表时间：
1988-08-01
影响因子：
24
通讯作者：
NEGRI, C
中科院分区：
文献类型：
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作者：
BAROLDI, G;CORALLO, S;NEGRI, C
连续26例艾滋病患者中，心脏主要表现为卡波西肉瘤2例，微灶性心肌脓肿1例，心内膜下梗塞坏死2例，收缩带坏死13例，淋巴细胞性心肌炎9例，心肌内淋巴细胞浸润，无肌细胞坏死7例，心外膜淋巴细胞浸润浸润4。没有患者出现充血性心力衰竭。然而，对 8 名患者进行的二维超声心动图显示，6 名患者存在功能异常（缩短分数范围为 18% 至 30%、球形、运动功能减退、心室轻度扩张）。这六名患者中有四名患有淋巴细胞性心肌炎，两名患者心肌和心外膜有淋巴细胞浸润，但无心肌细胞坏死。两例超声心动图正常，未见淋巴细胞浸润。定量分析表明，心脏淋巴细胞性心肌炎的参与本身不足以解释功能障碍。目前尚待确定：1）淋巴细胞性心肌炎是否可能是一种更广泛的分子疾病的迹象，2）它与扩张型心肌病的最终关系是什么。
In 26 consecutive cases with acquired immunodeficiency syndrome (AIDS) the main cardiac findings were Kaposi''s sarcoma in 2 cases, microfocal myocardial abscess in 1, subendocardial infarct necrosis in 2, contraction band necrosis in 13, lymphocytic myocarditis in 9, intramyocardial lymphocytic infiltrates without myocell necrosis in 7 and epicardial lymphocytic infiltrates in 4. No patient had congestive heart failure. However, two-dimensional echocardiography peformed in eight patients demonstrated functional abnormalities in six (fractional shortening ranging from 18 to 30%, globular shape, hypokinesia, mild ventricular dilation). Four of these six patients had lymphocytic myocarditis and two had lymphocytic infiltrates in the myocardium and epicardium without myocell necrosis. No lymphocytic infiltrates were seen in the two cases with a normal echocardiogram. Quantitative analysis indicated that involvement of the heart lymphocytic myocarditis is inadequate in itself to explain dysfunction. It remains to be established 1) whether lymphocytic myocarditis is a possible indication of a more widesperad molecular disorder, and 2) what its eventual relation with dilated cardiomyopathy will be.