Super Bronsted acid catalysis
Super Bronsted acid catalysis
复制标题
DOI：
10.1039/c0cc04867d
复制
发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Yamamoto, Hisashi
中科院分区：
文献类型：
--
作者：
Cheon, Cheol Hong;Yamamoto, Hisashi
Bronsted酸催化是现代有机合成中出现的一类新型催化剂。然而，为了使Bronsted酸催化的用途与成熟的Lewis酸催化一样广泛，开发既具有高反应活性又具有高选择性的Bronsted酸是可取的。在这篇专题文章中，我们将介绍我们在设计和开发强B酸及其在有机反应中的应用方面的成就。此外，我们还将描述Tf2NH催化的超硅烯醇醚的Mukaiyama Aldol反应。我们还将强调Bronsted酸催化和Lewis酸催化在反应性、化学选择性和立体选择性方面的差异。
Bronsted acid catalysis has emerged as a new class of catalysis in modern organic synthesis. However, in order to make the utility of the Bronsted acid catalysis as broad as the well-developed Lewis acid catalysis, it is desirable to develop Bronsted acids demonstrating both high reactivities and selectivities. In this feature article, we will present our achievement in the design and development of strong Bronsted acids and their application to organic reactions. Furthermore, we will describe the Tf2NH-catalyzed Mukaiyama aldol reaction of super silyl enol ethers. We also will highlight the differences in reactivity and chemo- and stereo-selectivity between Bronsted and Lewis acid catalysis.