Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120).
Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120).
复制标题
对由人类免疫缺陷病毒 1 型 (HIV-1) 或 HIV-1 外膜糖蛋白 (gp120) 制备的免疫刺激复合物 (ISCOM) 的免疫反应。
DOI：
10.1016/0264-410x(89)90164-3
复制
发表时间：
1989
期刊：
影响因子：
5.5
通讯作者：
Arthur,LO
中科院分区：
文献类型：
--
作者：
Pyle,SW;Morein,B;BessJr,JW;Akerblom,L;Nara,PL;NigidaJr,SM;Lerche,NW;Robey,WG;Fischinger,PJ;Arthur,LO
In mice, immunostimulatory complexes (ISCOMs) prepared from HIV-1 B external envelope glycoprotein (gp120) induced 10-fold higher antibody titres than gp120 emulsified in depot adjuvant, as measured by enzyme-linked immunosorbent assay (ELISA). Rhesus monkeys immunized with gp120 ISCOMs produced precipitating and virus neutralizing antibody titres equivalent to those seen in HIV-infected chimpanzees and humans. After multiple immunizations with HIV-1 B gp120 ISCOMs, a rhesus monkey developed a neutralizing response to the HIV-1 isolates RF and MN, but not to the CC isolate. Antisera from ISCOM-immunized rhesus monkeys recognized gp120 on the membranes of HIV-1 B-infected H9 cells, indicating the preservation of epitope structure in the ISCOMs matrix.
