The time to eradicate gastric cancer is now
The time to eradicate gastric cancer is now
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DOI：
10.1136/gut.2004.056549
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发表时间：
2005-06-01
期刊：
影响因子：
24.5
通讯作者：
Shiotani, A
中科院分区：
文献类型：
--
作者：
Graham, DY;Shiotani, A
胃癌仍然是全球最常见的癌症之一，每年造成超过100万人死亡。虽然分子发病机制尚不清楚，但幽门螺杆菌感染被认为是一种"必要但不致命“的原因，这并不奇怪，因为胃癌长期以来一直被认为与萎缩性胃炎有关。根除幽门螺杆菌有望在大约40年内基本消除胃癌和幽门螺杆菌相关消化性溃疡，从而降低总体死亡率。在美国，一般人群中胃癌的发病率较低，反映了萎缩性胃炎模式向非萎缩性胃炎模式的变化，以及中上层阶级幽门螺杆菌感染的低患病率和下降趋势。然而，根除这一重要病原体的计划必须在特定人群的患病率和结局的背景下考虑。
Worldwide gastric cancer remains one of the most common cancers, killing upwards of one million people each year. While the molecular pathogenesis remains unclear, infection with the bacterium Helicobacter pylori is considered a `` necessary but not sufficient'' cause, not surprisingly as gastric cancer has long been known to be associated with atrophic gastritis. Eradication of H pylori is expected to virtually eliminate gastric cancer and H pylori associated peptic ulcer within approximately 40 years and thus reduce overall mortality. In the USA, the incidence of gastric cancer in the general population is low, reflecting the change in the pattern of gastritis from atrophic to nonatrophic and in the low and decreasing prevalence of H pylori infection in the middle and upper classes. However, the plan for eradication of this important pathogen must be considered within the context of the prevalence and outcome within specific populations.