ECCENTRIC EXERCISE DECREASES GLUCOSE-TRANSPORTER GLUT4 PROTEIN IN HUMAN SKELETAL-MUSCLE
ECCENTRIC EXERCISE DECREASES GLUCOSE-TRANSPORTER GLUT4 PROTEIN IN HUMAN SKELETAL-MUSCLE
复制标题
DOI：
10.1113/jphysiol.1995.sp020553
复制
发表时间：
1995-02-01
影响因子：
5.5
通讯作者：
RICHTER, EA
中科院分区：
文献类型：
--
作者：
ASP, S;DAUGAARD, JR;RICHTER, EA
1. 离心运动会导致运动后糖原再合成受损。为了研究葡萄糖转运蛋白（GLUT4）蛋白的肌肉浓度的变化是否可能与其中有关，七名健康的年轻男性通过抵抗电机驱动装置强制的膝盖弯曲进行单腿离心运动。2．运动后，锻炼者和对照大腿中的 GLUT4 蛋白浓度没有变化。运动后第 1 天和第 2 天，运动肌肉中的 GLUT4 蛋白浓度分别为对照肌肉中浓度的 68 +/- 10 和 64 +/- 10%（平均值 +/- S.E.M.；P < 0.05），并在第 4 天和 7.3 天恢复到对照值。运动期间，肌糖原浓度从 404 +/- 44 降至 336 +/- 44 mmol（kg 干重）(-1) (P < 0.05)。运动后第1天和第2天，糖原浓度仍然显着低于对照大腿，但在第4天和第7天没有发现差异。4．尽管没有建立因果关系，但这些发现可能表明，肌肉中 GLUT4 蛋白浓度的降低，以及因此葡萄糖转运到肌肉细胞中的速率降低，可能与离心运动后观察到的浓度有关。
1. Eccentric exercise causes impaired postexercise glycogen resynthesis. To study whether changes in muscle concentration of the glucose transporter (GLUT4) protein might be involved, seven healthy young men performed one-legged eccentric exercise by resisting knee flexion enforced by a motor-driven device.2. The GLUT4 protein concentration in the exercised and in the control thigh was unchanged immediately after exercise. On days 1 and 2 after exercise, the GLUT4 protein concentration in the exercised muscle was 68 +/- 10 and 64 +/- 10% (means +/- S.E.M.; P < 0.05), respectively, of the concentration in the control muscle, and had returned to control values on days 4 and 7.3. The muscle glycogen concentration decreased from 404 +/- 44 to 336 +/- 44 mmol (kg dry wt)(-1) (P < 0.05) during exercise. The glycogen concentration remained significantly lower than in the control thigh on days 1 and 2 after exercise but on days 4 and 7 no differences were found.4. Although no cause-effect relationship was established, these findings may suggest that decreased muscle concentrations of GLUT4 protein, and, hence, a decreased rate of glucose transport into muscle cells, may be involved concentration seen after eccentric exercise.