Genetic modulation of energy metabolism in birds through mitochondrial function
Genetic modulation of energy metabolism in birds through mitochondrial function
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通过线粒体功能对鸟类能量代谢进行遗传调节
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Joseph B. Williams
中科院分区：
文献类型：
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作者：
B. Tieleman;Maaike A. Versteegh;A. Fries;B. Helm;N. Dingemanse;H. L. Gibbs;Joseph B. Williams
尽管它们对生理变异的进化至关重要，但决定动物能量消耗的遗传机制在很大程度上仍未得到研究。我们使用数量遗传学来证实，无论是质量特定的和整个生物体的基础代谢率（BMR）是遗传的圈养繁殖人口的石猫（石房蛤属）。建立在来自三个野生种群（欧洲，非洲和亚洲）的鸟类基础上，这些鸟类的基础代谢率不同。这表明BMR至少部分受多个未知核基因座的遗传控制，每个基因座对表型的影响有限。然后，我们测试了遗传效应的基础上BMR的细胞核共适应使用祖先群体之间的杂交高和低BMR（欧洲-非洲和亚洲-欧洲），不同的父母配置（femalehigh-malelow或femallow-malehigh）在每个组合的人口。具有不同亲本构型的杂交种具有平均相同的核DNA混合物，但线粒体DNA不同，因为它仅从母亲遗传。质量特异性BMR与不同的父母配置的杂种之间的差异，这意味着线粒体和核DNA的组合影响代谢率。因此，我们的研究结果暗示线粒体功能是能量代谢的重要调节器。结合代谢率的大量遗传性，并证实了线粒体基因组中的遗传差异，这些结果为进一步研究涉及线粒体和核基因的遗传控制机制奠定了基础，这些基因决定了整个生物体水平的代谢率。
Despite their central importance for the evolution of physiological variation, the genetic mechanisms that determine energy expenditure in animals have largely remained unstudied. We used quantitative genetics to confirm that both mass-specific and whole-organism basal metabolic rate (BMR) were heritable in a captive-bred population of stonechats (Saxicola torquata spp.) founded on birds from three wild populations (Europe, Africa and Asia) that differed in BMR. This argues that BMR is at least partially under genetic control by multiple unknown nuclear loci each with a limited effect on the phenotype. We then tested for a genetic effect on BMR based on mitochondrial–nuclear coadaptation using hybrids between ancestral populations with high and low BMR (Europe–Africa and Asia–Europe), with different parental configurations (femalehigh–malelow or femalelow–malehigh) within each combination of populations. Hybrids with different parental configurations have on average identical mixtures of nuclear DNA, but differ in mitochondrial DNA because it is inherited only from the mother. Mass-specific BMR differed between hybrids with different parental configurations, implying that the combination of mitochondrial and nuclear DNA affected metabolic rate. Therefore, our findings implicate mitochondrial function as an important regulator of energy metabolism. In combination with the substantial heritabilities of metabolic rate, and corroborated by genetic differences in the mitochondrial genome, these results set the stage for further investigations of a genetic control mechanism involving both mitochondrial and nuclear genes determining metabolic rate at the whole-organism level.
影响因子：
3.3
作者：
D. Houle
通讯作者：
D. Houle