Amyloidosis in juvenile chronic arthritis: a morbidity and mortality study.
Amyloidosis in juvenile chronic arthritis: a morbidity and mortality study.
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幼年慢性关节炎中的淀粉样变性：发病率和死亡率研究。
DOI：
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发表时间：
1993
影响因子：
3.7
通讯作者：
P. Woo
中科院分区：
文献类型：
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作者：
J. David;O. Vouyiouka;Ansell Bm;A. Hall;P. Woo
对 79 名患有反应性淀粉样变性的青少年关节炎患者进行了一项回顾性研究，从淀粉样变性发作起平均时间为 10 年（3 个月至 24.25 年）。诊断 10 年后，接受苯丁酸氮芥治疗的患者 (n = 57) 中有 80% 存活，而未接受苯丁酸氮芥治疗的患者 (n = 19) 的存活率为 23.5%。 82.3% 的死亡原因是肾衰竭，11.7% 的死亡原因是感染。副作用包括一名接受苯丁酸氮芥治疗的患者出现急性白血病，七名患者出现严重白细胞减少症，四名患者出现血小板减少症。十五名患者不再接受细胞毒治疗并处于缓解状态。对生育状况的分析显示，23 名接受苯丁酸氮芥治疗的育龄妇女中有 3 名妇女正常分娩 5 名，2 名终止妊娠。六名女性患有卵巢功能衰竭。这些男性患者中没有一个是孩子的父亲。
A retrospective study of 79 juvenile arthritic patients with reactive amyloidosis for a mean of 10 years (3 months-24.25 years) from the onset of amyloidosis was performed. Eighty percent of those treated with chlorambucil (n = 57) were alive compared with 23.5% of patients not treated with chlorambucil (n = 19) 10 years after diagnosis. Renal failure was the cause of death in 82.3% and infection in 11.7%. Side effects included one chlorambucil-treated patient who developed acute leukaemia, and seven patients who developed severe leucopenia and four thrombocytopenia. Fifteen patients are no longer on cytotoxic therapy and are in remission. Analysis of their fertility status showed that there were 5 normal births in 3 women and 2 terminations of pregnancy in 23 chlorambucil-treated women of child bearing age. Six women had ovarian failure. None of the male patients fathered a child.