Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression
Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression
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DOI：
10.1016/s0925-4773(01)00338-0
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发表时间：
2001-05-01
影响因子：
2.6
通讯作者：
Takada, S
中科院分区：
文献类型：
--
作者：
Ikeya, M;Takada, S
在脊椎动物中，沿前后轴的每个椎骨都具有独特的结构。最近研究表明，在原条外胚层和/或尾芽中表达的几种转录因子和细胞信号分子在小鼠发育过程中对建立正确的椎骨前后特化起着至关重要的作用。在此，我们报道Wnt - 3a突变体在其整个体轴的椎骨中呈现同源异型转化。此外，在Wnt - 3a突变体胚胎的原条和尾芽区域观察到cdx - 1表达降低，cdx - 1突变会导致如Wnt - 3a突变体中出现的前部转化。这些结果表明，Wnt - 3a对于椎骨正确的前后模式形成是必需的，并且cdx - 1可能是这一过程中Wnt - 3a信号传导的中介基因之一。（C）2001年爱思唯尔科学爱尔兰有限公司。保留所有权利。
In vertebrates, each vertebra along the anteroposterior axis has a characteristic structure. It has recently been shown that several transcription factors and cell signaling molecules expressed in the primitive streak ectoderm and/or the tailbud play essential roles in establishing the correct anteroposterior specification of vertebrae during mouse development. Here, we report that Wnt-3a mutants exhibit homeotic transformations in the vertebrae along their entire body axis. In addition, reduced expression of cdx-1, the mutation of which results in an anterior transformation, as occurs in Wnt-3a mutants, was observed in the primitive streak and tail bud region of Wnt-3a mutant embryos. These results indicate that Wnt-3a is necessary for correct anteroposterior patterning of vertebra, and that cdx-1 may be one of the mediator genes of Wnt-3a signaling in this process. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.