Quantification of regional myocardial function by rapid cine MR imaging.
Quantification of regional myocardial function by rapid cine MR imaging.
复制标题
通过快速电影 MR 成像量化局部心肌功能。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Charles B. Higgins
中科院分区：
文献类型：
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作者：
P. Pflugfelder;U. Sechtem;R. White;Charles B. Higgins
本文评价了13例正常人和15例经超声心动图和/或对比心动图证实的缺血性心脏病和局部室壁运动异常患者的快速(电影)磁共振成像对左心功能的定量能力。使用部分翻转角度、短重复时间和梯度重聚焦回波获得15~20个MR图像/心动周期。用电影技术定性评价左心室赤道段的局部室壁运动，定量测量该平面上6个左心室节段的舒张末和收缩末期心肌厚度。在正常志愿者中，所有节段的室壁运动均正常。正常人收缩期壁增厚的不均一性在后间隔段为33%+/-17%，在后间隔段为66%+/-29%。整体收缩期壁增厚48%+/-28%。从MR图像的电影显示，缺血性心脏病患者的90个节段中有40个节段有异常的室壁运动，这与超声心动图或对比心动图的结果有很好的相关性。21个节段运动迟缓，15个节段运动停滞，4个节段运动障碍。在缺血性心脏病患者中，室壁运动正常节段的室壁增厚百分率为43%+/-31%，运动减慢节段为6%+/-18%，运动迟缓节段为-4%+/-24%，运动障碍节段为-13%+/-25%。40个异常节段中，31个节段的绝对收缩期室壁厚度小于2 mm，3个节段的绝对收缩期壁厚度大于2 mm。快速采集、改进的时间分辨率和电影显示能力使这种新的MR技术不仅可用于定性评估心壁运动，还可用于定量评价局部心肌功能。
The capability of rapid (cine) MR imaging to quantitate left ventricular function was assessed in 13 normal subjects and in 15 patients with ischemic heart disease and regional wall-motion abnormalities proved by echocardiography and/or by contrast ventriculography. Fifteen to 20 MR images/cardiac cycle were acquired by using partial flip angles, short repetition times, and gradient-refocused echoes. Regional wall motion was assessed qualitatively in the equatorial left ventricular section by using the cine display and quantitatively by measuring myocardial thickness at end-diastole and at end-systole in six left ventricular segments in this plane. In normal volunteers wall motion was normal in all segments. Heterogeneity of systolic wall thickening was observed in normal subjects, ranging from 33% +/- 17% in the posteroseptal segment to 66% +/- 29% in the posterior segment. Overall systolic wall thickening was 48% +/- 28%. From the cinematic display of MR images, abnormal wall motion was observed in 40 of 90 segments in patients with ischemic heart disease, which correlated well with results of echocardiography or contrast ventriculography. Twenty-one segments were hypokinetic, 15 were akinetic, and four were dyskinetic. In patients with ischemic heart disease, percentage systolic wall thickening was 43% +/- 31% in the segments with normal wall motion, 6% +/- 18% in hypokinetic segments, -4% +/- 24% in akinetic segments, and -13% +/- 25% in dyskinetic zones. Absolute systolic wall thickening was less than 2 mm in 31 of 40 abnormal segments and was greater than 2 mm in only three. Rapid acquisition, improved temporal resolution, and the capacity for cine display make this new MR technique potentially useful not only for qualitative assessment of cardiac wall motion, but also for quantification of regional myocardial function.